Results 71 to 80 of about 191,418 (345)

Human Pluripotent Stem Cell-Derived Micropatterned Ectoderm Allows Cell Sorting of Meso-Endoderm Lineages

Frontiers in Bioengineering and Biotechnology, 2022
The human developmental processes during the early post-implantation stage instruct the specification and organization of the lineage progenitors into a body plan.
Yang Yang, Yang Yang, Cecilia Laterza, Cecilia Laterza, Hannah T. Stuart, Hannah T. Stuart, Federica Michielin, Federica Michielin, Onelia Gagliano, Onelia Gagliano, Anna Urciuolo, Anna Urciuolo, Anna Urciuolo, Nicola Elvassore, Nicola Elvassore, Nicola Elvassore   +15 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Rotiferan Hox genes give new insights into the evolution of metazoan bodyplans

Nature Communications, 2017
Rotifers are microscopic animals with an unusual, nonsegmented body plan consisting of a head, trunk and foot. Here, Fröbius and Funch investigate the role of Hox genes—which are widely used in animal body plan patterning—in rotifer embryogenesis and ...
Andreas C. Fröbius, Peter Funch
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Sexual signaling pattern correlates with habitat pattern in visually ornamented fishes

Nature Communications, 2020
Sensory drive theory posits that selection on sexual signals should depend on the environmental background. Here, Hulse et al. analyze the spatial statistics of body patterning in 10 darter fish species and find a correlation with habitat spatial ...
Samuel V. Hulse, Julien P. Renoult, Tamra C. Mendelson   +2 more
doaj   +1 more source

Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort. [PDF]

, 2019
Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms.
Aaron, Phylicia A, Affolter, Verena K, Dennis, Michael, Everett, Angela D, Fedor, Dawn M, Gelli, Angie, Krois, Charles R, McHardy, Ian, Napoli, Joseph L, Sharon, Victoria R, Singapuri, Anil, Thompson, George R, Varjonen, E Katarina, White, Stephen D, Wiederhold, Nathan P, Yoo, Hong Sik   +15 more
core  

Cell polarity and patterning by PIN trafficking through early endosomal compartments in Arabidopsis thaliana [PDF]

, 2013
PIN-FORMED (PIN) proteins localize asymmetrically at the plasma membrane and mediate intercellular polar transport of the plant hormone auxin that is crucial for a multitude of developmental processes in plants.
De Rycke, Riet, Feraru, Ioan Mugurel, Friml, Jiri, Kakimoto, Tatsuo, Kitakura, Saeko, Rakusova, Hana, Robert, Stephanie, Tanaka, Hirokazu, Uemura, Tomohiro   +8 more
core   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Uncoupling of complex regulatory patterning during evolution of larval development in echinoderms

BMC Biology, 2010
Background Conservation of orthologous regulatory gene expression domains, especially along the neuroectodermal anterior-posterior axis, in animals as disparate as flies and vertebrates suggests that common patterning mechanisms have been conserved since
Jennings Charlotte K, Martik Megan L, Yankura Kristen A, Hinman Veronica F   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source