Results 81 to 90 of about 2,501,678 (260)

Diet Affects the Temperature–Size Relationship in the Blowfly Aldrichina grahami

Insects
In warmer environments, most ectotherms exhibit a plastic reduction in body size (the temperature–size rule, TSR). However, in such environments, growth is usually accelerated and would be expected to result in maturation at a larger body size, leading ...
Guanjie Yan, Dandan Li, Guangshuai Wang, Lingbing Wu   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Over or Under? Mental Representations and the Paradox of Body Size Estimation

Frontiers in Psychology, 2021
Kevin R. Brooks, Kevin R. Brooks, Richard J. Stevenson, Richard J. Stevenson, Ian D. Stephen, Ian D. Stephen   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Temperature‐Dependence Assumptions Drive Projected Responses of Diverse Size‐Based Food Webs to Warming

Earth's Future
Food web projections are critical for evaluating potential risks to ecosystems and fisheries under global warming. The temperature dependence of biological processes and regional differences in food web structure are two important sources of uncertainty ...
J. C. P. Reum, P. Woodworth‐Jefcoats, C. Novaglio, R. Forestier, A. Audzijonyte, A. Gårdmark, M. Lindmark, J. L. Blanchard   +7 more
doaj   +1 more source

Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion

eLife
Smads and their transcription factor partners mediate the transcriptional responses of target cells to secreted ligands of the transforming growth factor-β (TGF-β) family, including those of the conserved bone morphogenetic protein (BMP) family, yet only
Mehul Vora, Jonathan Dietz, Zachary Wing, Karen George, Jun Kelly Liu, Christopher Rongo, Cathy Savage-Dunn   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Estimating Average Body Size of Sets of Bodies.

, 2019
In two behavioral experiments, we demonstrated that human observers can extract average body size from a group ofindividuals. In Experiment 1, we asked 38 participants to estimate the average body size from a group of 5, 10 or 15bodies that were presented in various angles of view (Profile, Three-Quarter, Frontal, and Mixed).
To, Michelle, Brand, James, Hampton, Georgia, Tovee, Martin   +3 more
openaire   +1 more source