Results 181 to 190 of about 1,113,790 (268)

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Bone Modelling and Remodelling in Cold Environment. [PDF]

Biomolecules
Xue L, Guan Q, Zhang L.
europepmc   +1 more source

Supplementary Material for: Heat Shock Factor 1 Deficiency Affects Systemic Body Temperature Regulation

, 2015
Marc Ingenwerth, Erik Noichl, Anna Stahr, Horst‐Werner Korf, Hans Reinke, Charlotte von Gall   +5 more
openalex   +2 more sources

Short‐Chain Fatty Acids Modulate Anti‐ROR1 CAR T‐Cell Function and Exhaustion in an Intestinal Adenocarcinoma‐on‐Chip Model

Advanced Healthcare Materials, EarlyView.
Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner, Adrian Feile, Miriam Alb, Michael Hudecek, Philip Hewitt, Alexander S. Mosig   +5 more
wiley   +1 more source

Thermogenesis and Energy Metabolism in Brown Adipose Tissue in Animals Experiencing Cold Stress. [PDF]

Int J Mol Sci
Zhang X, Xiao J, Jiang M, Phillips CJC, Shi B.   +4 more
europepmc   +1 more source

CRISPR/Cas9-mediated in vivo gene editing reveals that neuronal 5-HT1A receptors in the dorsal raphe nucleus contribute to body temperature regulation in mice

, 2019
Naoya Nishitani, Yu Ohmura, Kazuki Nagayasu, Norihiro Shibui, Shuji Kaneko, Akiko Ohashi, Takayuki Yoshida, Akihiro Yamanaka, Mitsuhiro Yoshioka   +8 more
openalex   +2 more sources

Organoid‐Like Neurovascular Spheroids Promote the Recovery of Hypoxic‐Ischemic Skin Flaps Through the Activation of Autophagy

Advanced Healthcare Materials, EarlyView.
Highly sprouting organoid‐like neurovascular spheroids (NVUs) are developed, featuring cell‐loaded poly‐3‐hydroxybutyrate 4‐hydroxybutyrate(P34HB) porous microsphere cores embedded within Gelatin Methacryloyl. NVUs formed complex vascular plexuses and secreted extracellular matrix in vitro, simulating autologous nerves and blood interaction.
Junjin Jie, Jingyi Ju, Zhenxing Wang, Jun Chen, Lin‐Ping Wu, Jiaming Sun   +5 more
wiley   +1 more source

Sex differences in metabolic regulation by Gi/o-coupled receptor modulation of exocytosis. [PDF]

Front Pharmacol
Young M, Ceddia RP, Thompson-Gray A, Reyes D, Cassada JB, Ayala JE, McGuinness OP, Collins S, Hamm HE.   +8 more
europepmc   +1 more source

A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals

Advanced Healthcare Materials, EarlyView.
A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin, Kyungtae Kim, Jaeseung Lee, Johyeon Nam, Eunha Baeg, Chaeyeon You, Hanseul Choi, Minji Kim, Chun Kee Chung, Jae Geun Kim, Jong Hyun Ahn, Miryung Han, Jibum Kim, Sungchil Yang, Sung Q Lee, Sunggu Yang   +15 more
wiley   +1 more source

Adaptive Thermogenesis and Lipid Metabolism Modulation in Inguinal and Perirenal Adipose Tissues of <i>Hezuo Pigs</i> in Response to Low-Temperature Exposure. [PDF]

Cells
Li Y, Shi HX, Li J, Du H, Jia R, Liang YH, Huang XY, Gao XL, Gun SB, Yang QL.   +9 more
europepmc   +1 more source