Results 41 to 50 of about 9,493,872 (278)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Acta Universitatis Palackianae Olomucensis. Gymnica, 2009 BACKGROUND: The application of lymphatic massages has a highly preventive effect as it reinforces the drainage and transport functions of the lymph pump and thus activates the lymphatic flow and helps detoxify the body.
Jarmila Riegerová +3 more
doaj
Водное хозяйство России: проблемы, технологии, управление, 2021 Information on water bodies on the territory of the Russian Federation is contained in the State Water Register (SWR). Water bodies that have not yet been represented in the State Water Register are actually taken out of the legal framework of the Water
Timur M. Aksyanov, Olga V. Gorelits
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Many-body screening effects in liquid water
Nature Communications, 2023 The screening arising from many-body excitations is a crucial quantity for describing absorption and inelastic X-ray scattering (IXS) of materials. Similarly, the electron screening plays a critical role in state-of-the-art approaches for determining the
Igor Reshetnyak +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Italian Journal of Animal Science, 2010 Thermo-regulation in swamp buffaloes has been investigated as an adaptive system to hot-humid climates, and several distinctive physiological responses were noted.
S. Chanpongsang, N. Chaiyabutr, A. Koga
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Open Geosciences, 2021 Xiaolangdi Reservoir is a key control project to control the water and sediment in the lower Yellow River, and a timely and accurate grasp of the reservoir’s water storage status is essential for the function of the reservoir.
Wang Ruimeng +8 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source