Results 101 to 110 of about 4,888,430 (248)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Glucagon-like peptide 1 therapy as an adjunct treatment after bariatric metabolic surgery: Preliminary experience from an East-Asian medical center

Asian Journal of Surgery, 2023
Ting-Wei Chang, Ivy Ya-Wei Huang, Chih-Kun Huang, Po-Chih Chang   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Effect of Acupuncture Therapy on Body Compositions in Patients with Obesity

针刺研究, 2017
Objective To observe the clinical effectiveness of acupuncture intervention in weight reduction by modulating body compositions in obesity patients.Methods A total of 71 obesity patients during weight-loss procedure were allocated to acupuncture ...
ZHANG Hui-min, WU Xue-liang, JIANG Chao, SHI Rong-xing   +3 more
doaj  

Daptomycin dosing in obese patients: analysis of the use of adjusted body weight actual body weight

Therapeutic Advances in Infectious Disease, 2019
Background: Food and Drug Administration–approved daptomycin dosing uses actual body weight, despite limited dosing information for obese patients. Studies report alterations in daptomycin pharmacokinetics and creatine phosphokinase elevations associated
Ashley N. Fox, Winter J. Smith, Katherine E. Kupiec, Stephanie J. Harding, Beth H. Resman-Targoff, Stephen B. Neely, Bryan P. White, Ryan E. Owens   +7 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Body weight of aradi goat kids in Saudi Arabia at different ages and affecting factors

, 1989
Animal Production Department, College of Agriculture, King Saud University, Riyadh, Saudi ArabiaThirty-one males and 19 females of Aardi goat kids were used to investigate the weights at birth and 3, 6, 9 and 12 months of age.
Bakkar, M.N., Mogawer, H.H., Salah, M.S.
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The weight game in elite junior rowers: influence of body weight subdivisions on strength, power, and speed performance across distances from 100 to 6000 m

Human Movement
Purpose The proposal to eliminate body weight (BW) subcategories in senior rowing at the 2028 Olympic Games may impact smaller-scale competitions, particularly in the junior category, favouring heavier athletes due to the contribution of BW to rowing ...
Paulo F. de Almeida-Neto, Luiz Felipe da Silva, Steven E. Riechman, Bianca Miarka, Radamés Maciel Vítor Medeiros, Felipe J. Aidar, Paulo Moreira Silva Dantas, Gilmara Gomes de Assis, Breno Guilherme de Araújo Tinôco Cabral   +8 more
doaj   +1 more source