Results 121 to 130 of about 1,403,395 (311)
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Stress levels, eating habits, and body weight of adults in Higher Education Institutions
O Mundo da SaúdeTo analyze the prevalence of perceived stress during the period of social isolation imposed by the Covid-19 pandemic, according to sociodemographic characteristics, food consumption, and other health-related behaviors, among adult workers and students ...
Gabriela Baptista +5 more
doaj +1 more source
Body weight changes in female patients with prolactinoma treated with bromocriptin [PDF]
Medicinski Glasnik, 2007 The aim of this study was to determine the body weight changes in female patients with bromocriptin treated prolactinoma. Seventeen hyperprolactinemic pre-menopausal female with prolactinoma, aged 18-45 years, with body mass index (BMI) 30+/-2,1kg/m2 ...
Z. Velija-Ašimi;
doaj
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
NutraceuticalsCurcumin is widely used for its antioxidant and anti-inflammatory properties, but its poor oral bioavailability has driven the development of advanced formulations such as CAVACURMIN®, a γ-cyclodextrin-based curcumin complex with enhanced absorption ...
Heiko Zipp +4 more
doaj +1 more source
MULTIVARIATE ANALYSIS ON PHENOTYPIC TRAITS OF BODY MEASUREMENT IN SWAMP BUFFALO ( Bubalus bubalis) [PDF]
, 2009 The objective of this research was to study the relationship between body measurement and body weight and closeness among swamp buffalo at three populations in Central Java.
Kurnianto, E. (E) +11 more
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source