Results 101 to 110 of about 514,621 (311)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Family nurturance and the development of obsession with body image and weight [PDF]

open access: yes, 1999
Plan BThe purpose of this study was to investigate the correlation between family nurturance and the obsession with body image and weight in females enrolled in some form of secondary education in Wisconsin or Alabama.
Rastall, Jodi
core  

Gain of body weight.

open access: yes, 2019
Hyperandrogenism enhanced the weight gain of female rats (*p = 0.0031, 0.0047 and 0.0067 vs. ♀D+ for T♀D+ (g), T♀D+ (%) and T♀D- (%), respectively; n = 10–11; two-way ANOVA followed by Tukey’s post hoc test).
Emil Monos (619618)   +11 more
core   +1 more source

Prepregnancy body mass index, gestational weight gain, and birth weight in the BRISA cohort

open access: yesRevista de Saúde Pública, 2018
OBJECTIVE To analyze the effects of maternal pre-pregnancy body mass index and weight gain during pregnancy on the baby's birth weight. METHODS We conducted a cross-sectional study with 5,024 mothers and their newborns using a Brazilian birth cohort ...
Raina Jansen Cutrim Propp Lima   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Relationship between Maternal Height, BMI and Weight Gain and Dystocia in Pregnant Women Referred to Maternity Wards of Qom Public Hospitals in 2006 [PDF]

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2009
Background and ObjectivesHeight, abnormal BMI & weight gain play a very important role in the outcome of pregnancy that hard labor or dystocia is one of the main reasons of the mortality of mothers.
H. Ahmari Tehran   +4 more
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Estimation of a Dynamic Model of Weight [PDF]

open access: yes
The ongoing debate about the economic causes of obesity has focused on the changing relative prices of diet and exercise. This paper uses a model that explicitly includes time and spatially varying community-level urbanicity and price measures as ...
Edward C. Norton   +3 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Association of third trimester body mass index and pregnancy weight gain in obese pregnant women to umbilical artery atherosclerotic markers and fetal outcomes [PDF]

open access: yes, 2020
Background: Obesity in pregnancy is a chronic inflammatory condition that can damage the cardiovascular system. This study aimed to demonstrate the correlation of third trimester body mass index (BMI) and pregnancy weight gain in obese pregnant women to ...
Agus Sulistyono   +4 more
core  

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