Results 51 to 60 of about 6,036 (256)

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

Study of autumn sowing of sugar beet (Beta vulgaris L. ) in Fasa area [PDF]

Majallah-i Chughundar-i Qand, 2013
In order to determine the optimum sowing and harvesting dates of two autumn sugar beet cultivars (Bete vulgaris L.) and develop the planting area of this crop, the present research was conducted in Fasa, Iran during 2005-2008.
G. R. Ashraf Mansoori, M. Sharifi, F. Hamdi   +2 more
doaj   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Inflorescence Development and the Role of LsFT in Regulating Bolting in Lettuce (Lactuca sativa L.)

Frontiers in Plant Science, 2018
Lettuce (Lactuca sativa L.) is one of the most important leafy vegetable that is consumed during its vegetative growth. The transition from vegetative to reproductive growth is induced by high temperature, which has significant economic effect on lettuce
Zijing Chen, Yingyan Han, Kang Ning, Yunyu Ding, Wensheng Zhao, Shuangshuang Yan, Chen Luo, Xiaotang Jiang, Danfeng Ge, Renyi Liu, Qian Wang, Xiaolan Zhang   +11 more
doaj   +1 more source

A single amino acid residue substitution in BraA04g017190.3C, a histone methyltransferase, results in premature bolting in Chinese cabbage (Brassica rapa L. ssp. Pekinensis)

BMC Plant Biology, 2021
Background Flowering is an important inflection point in the transformation from vegetative to reproductive growth, and premature bolting severely decreases crop yield and quality.
Chong Tan, Jie Ren, Lin Wang, Xueling Ye, Wei Fu, Jiamei Zhang, Meng Qi, Hui Feng, Zhiyong Liu   +8 more
doaj   +1 more source

The bolt

Góry, Literatura, Kultura, 2021
The first bolts in Poland were fixed in Góry Sokole (Falcon Mountains). This was a climbing technique which became a turning point in rock climbing and changed the ethical framework of mountaineering. The first device for fixing bolts was developed by Tadeusz Zipser, a young mountaineer and graduate of the Wrocław University of Science and Technology ...
openaire   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Genome sequencing-based transcriptomic analysis reveals novel genes in Peucedanum praeruptorum

BMC Genomic Data, 2023
Background Peucedanum praeruptorum Dunn, a traditional Chinese herbal medicine, contains coumarin and volatile oil components that have clinical application value. However, early bolting often occurs in the medicinal materials of Apiaceae plants.
Cheng Song, Yingyu Zhang, Yunpeng Zhang, Shanyong Yi, Haoyu Pan, Ranran Liao, Yuanyuan Wang, Bangxing Han   +7 more
doaj   +1 more source

Operando Electrochemical Formation of Integrated Ni‐Fe Oxyhydroxide Anode for Durable Anion Exchange Membrane Water Electrolyzer

Advanced Science, EarlyView.
The interfacial stability and activity of Ni‐Fe‐based AEMWE anodes can be directly enhanced by operando voltage‐cycling in a FeOOH‐containing electrolyte. This process simultaneously induces Ni oxidation and Fe incorporation, forming an integrated, porous (Fe, Ni)OOH layer with high conductivity and durability.
Euntaek Oh, Jonghyun Hyun, Hojin Lee, Changsoo Lee, Jang Yong Lee, Dong Wook Lee, Kyunghwa Seok, Jeesoo Park, Susung Kim, Gisu Doo, Hee‐Tak Kim   +10 more
wiley   +1 more source

Full-length transcriptome and RNA-Seq analyses offer new insights into the mechanisms underlying early bolting in Peucedanum praeruptorum Dunn (Apiaceae)

Industrial Crops and Products
Peucedanum praeruptorum Dunn, known as “Qianhu”, is a perennial herb with high value in traditional Chinese medicine. However, early bolting during cultivation significantly reduces both quality and yield, posing major challenges for its agricultural and
Mengli Zhou, Qi Wang, Siyu Chen, Weiyi Tang, Zongsuo Liang, Ruihong Wang   +5 more
doaj   +1 more source