Results 101 to 110 of about 787 (249)

Light‐Controlled Modulation of 15‐Lipoxygenase‐1 Regulates Intestinal Inflammatory Signaling

Angewandte Chemie, EarlyView.
The developed target‐guided strategy enables the rational design of diazo‐based photoswitchable inhibitors of 15‐lipoxygenase‐1. Distinct molecular architectures program opposite light‐dependent activity, allowing on‐demand control of enzyme inhibition.
Anastasia Louka, Eirini‐Eleni Kalaitzaki, Athanasios Panousis, Sotirios Bonoras, Charalampos Livas, George Froudakis, Ioannis Drygiannakis, Athina Damianaki, George Kolios, Vassilis Valatas, Nikolaos Eleftheriadis   +10 more
wiley   +2 more sources

Buena fe subjetiva y buena fe objetiva. Equívocos a los que conduce la falta de claridad en la distinción de tales conceptos

Revista de Derecho Privado (Bogota. 1997), 2009
El presente escrito tiene por objeto dejar en evidencia la confusión que en cierto sector de la jurisprudencia colombiana existe entre el concepto de buena fe objetiva y el concepto de buena fe subjetiva, que ha trascendido, por demás, a una parte de la ...
Martha Lucía Neme Villarreal
doaj   +2 more sources

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

ÎNCĂLCAREA BUNEI-CREDINŢE – ELEMENT DE APRECIERE A CLAUZEI ABUZIVE ÎN CONTRACTUL DE CONSUM

Studia Universitatis Moldaviae: Stiinte Sociale, 2012
L’idée de la bonne foi contractuelle est mise en oeuvre pour justifier l’annulation de certaines clauses d’irresponsabilité ou de non-obligation qui déséquilibrent manifestement les relations contractuelles.
USM ADMIN
doaj  

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

The Green Virtues of Chinese Protectionism: A Comparative Analysis of EU and US Responses to the China Garbage Shock

Revue Interventions Économiques
Can economic protectionism in the Global South induce environmental reforms in the Global North? In 2017, China enacted “Operation National Sword,” which banned the import of a subset of internationally traded waste and scrap products.
Rachel L. Wellhausen, Jean-Baptiste Velut   +1 more
doaj   +1 more source

Neither Positive Nor Negative Aspiration Before Filler Injection Should Be Relied Upon as a Safety Maneuver. [PDF]

Aesthet Surg J, 2021
Goodman GJ, Magnusson MR, Callan P, Roberts S, Hart S, McDonald CB, Liew S, Porter C, Corduff N, Clague M.   +9 more
europepmc   +1 more source

A bona fide MAP kinase

Journal of Biological Chemistry, 2022
openaire   +2 more sources

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source