Results 81 to 90 of about 1,371 (289)

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Acquisitive perscription in Roman Legal Tradition with a Special Review of the bona fides requirement

, 2023
Razmatrajući problem evidencije prava vlasništva na nekretninama, u praksi se često događa da faktično stanje nije usklađeno s pravnim stanjem. Takav problem posebice bilježimo na selima gdje nakon sklopljenih ugovora kupoprodaji ili zamjeni, ili drugih ...
Palian, Ivana
core   +2 more sources

Regaining Lost Ground and Countering the Anti-Apartheid Sports Movement: The Committee for Fairness in Sport (CFFS), Bureau of State Security (BOSS), and the International Sports Boycott, 1973-1978

African Studies Quarterly
Because of the determined effort of the anti-apartheid movement to secure South Africa’s expulsion from the international sports arena, the Bureau of State Security (BOSS) established the Committee for Fairness in Sport (CFFS) in 1973.
Hendrik Snyders
doaj   +1 more source

Warning: Humans cannot reliably detect speech deepfakes. [PDF]

PLoS One, 2023
Mai KT, Bray S, Davies T, Griffin LD.
europepmc   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Faculté de droit de l'université de Bale.- Aequitas und Bona fides.

, 1956
Faculté de droit de l'université de Bale.- Aequitas und Bona fides.. In: Revue internationale de droit comparé. Vol. 8 N°3, Juillet-septembre 1956.

core   +1 more source

«Bona fides» tra storia e sistema (2. edizione)

, 2010
La bona fides come fondamento romano dei diritti odierni è ripercorsa nei suoi sviluppi europei e latinoamericani, attraverso una indagine storica delle vie diverse della tradizione giuridica e una serie di istituti ad essa collegati (sopravvenienza e ...
Cardilli, R
core  

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source