Results 71 to 80 of about 89,005 (231)

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

Advanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang, Dayu Hu, Yaqi Dai, Aoyi Geng, Renxiang Guan, Hao Quan, Brett A. McGregor, Zhihan Wang, Nadeem Khan, Hongsheng Zhang, Jinghua Zhang, Mingyang Xia, Xiaoqiong Gu, Di Che, Junguk Hur, Xiaoyu Cui, Kai Guo   +16 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Legal Pluralism, uBuntu and the Use of Open Norms in the South African Common Law of Contract

Potchefstroom Electronic Law Journal, 2019
In this article, a comparison is drawn between the role of good faith in the development of the Roman law of contract and the emerging role of ubuntu in the South African common law of contract.
Hanri Magdalena Du Plessis
doaj   +1 more source

An ATP‐Driven N Protein–DDX21 Molecular Switch Dynamically Controls SARS‐CoV‐2 RNA G‐Quadruplex Heterogeneity

Advanced Science, EarlyView.
An ATP‐driven molecular switch, comprising viral nucleocapsid (N) protein and host helicase DDX21, dynamically modulates SARS‐CoV‐2 RNA G‐quadruplex (G4) heterogeneity. These viral G4s feature non‐canonical ion‐dependence and act as energy‐sensitive structural checkpoints.
Ya‐Ting Zheng, Li‐Yan Zhai, Jie Jin, Qiu‐Ying Chen, Hang Fu, Xue‐Qian Sun, Ying Lu, Hui Li, Xi‐Miao Hou   +8 more
wiley   +1 more source

Bona fides, uberrima fides e boa-fé: transição conceitual e função estruturante no contrato de seguro [PDF]

, 2022
A boa-fé apresenta especial significado no contrato de seguro. Daí a justificativa para o reconhecimento da sua natureza uberrima fides, a exigir, dos contratantes, que observem a máxima boa-fé ou a “mais estrita boa-fé e veracidade” na formação e ...
Petersen, Luiza Linhares Moreira
core   +1 more source

Relevant norms of Roman law in Russian civil legislation

Russian Studies in Law and Politics
Background. The article examines the impact of Roman Law principles on contemporary Russian civil legislation. The authors analyze key legal institutions, such as principle of bona fides, easements (servitutes), contractural obligations (pacta sunt ...
Mikhail Y. Ushakov, Oleg A. Mekka
doaj   +1 more source

Harmonising Legal Values and uBuntu: The Quest for Social Justice in the South African Common Law of Contract

Potchefstroom Electronic Law Journal, 2019
In this article, a comparison is drawn between the role of good faith in the development of the Roman law of contract and the emerging role of ubuntu in the South African common law of contract.
Hanri Magdalena Du Plessis
doaj   +1 more source

PENERAPAN ASAS BONA FIDES DALAM PERJANJIAN JUAL BELI MELALUI SISTEM ELEKTRONIK (E-COMMERCE) [PDF]

Abstrak Tujuan penelitian ini untuk mengetahui penerapan asas bona fides dalam perjanjian jual beli melalui sistem elektronik (e-commerce).  Perkembangan teknologi informasi dan komunikasi telah mengubah cara manusia melakukan transaksi jual beli ...
Winta Hayati
core   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source