Results 51 to 60 of about 787 (249)
Advanced Science, EarlyView.This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li +4 more
wiley +1 more source
Shakespeare in the Head for Health: A Reality Orientation Option for Alzheimer’s Worriers
Nonpartisan Education Review, 2009 By way of bona fides: As with many Americans, my own extended family has over the years given me plenty of direct contact with senile dementia, the general label for Alzheimer’s disease.
Robert Oliphant
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The role of public policy reservation in international contracts [PDF]
Zbornik Radova: Pravni Fakultet u Novom Sadu, 2018 Among the main roles of public policy in the field of international contracts is its role of the object of protection of the public policy reservation, one of the most important tools of private international law, which enables the forum to refuse ...
Ristić Bojana D.
doaj
Potchefstroom Electronic Law Journal, 2019 In this article, a comparison is drawn between the role of good faith in the development of the Roman law of contract and the emerging role of ubuntu in the South African common law of contract.
Hanri Magdalena Du Plessis
doaj +1 more source
Advanced Science, EarlyView.Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li +8 more
wiley +1 more source
Legal Pluralism, uBuntu and the Use of Open Norms in the South African Common Law of Contract
Potchefstroom Electronic Law Journal, 2019 In this article, a comparison is drawn between the role of good faith in the development of the Roman law of contract and the emerging role of ubuntu in the South African common law of contract.
Hanri Magdalena Du Plessis
doaj +1 more source
Dynamic Regulation of Endogenous Transcription Factor Hubs at Single‐Molecule Resolution
Advanced Science, EarlyView.This study combines single‐molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms neomorphic hubs that dynamically assemble and dissolve. The hubs are regulated during mitosis, by RNA, and by specific chemicals.
Shawn Yoshida +4 more
wiley +1 more source
Relevant norms of Roman law in Russian civil legislation
Russian Studies in Law and PoliticsBackground. The article examines the impact of Roman Law principles on contemporary Russian civil legislation. The authors analyze key legal institutions, such as principle of bona fides, easements (servitutes), contractural obligations (pacta sunt ...
Mikhail Y. Ushakov, Oleg A. Mekka
doaj +1 more source
Advanced Science, EarlyView.ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang +7 more
wiley +1 more source
Advanced Science, EarlyView.The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao +8 more
wiley +1 more source