Results 61 to 70 of about 81,644 (285)

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

open access: yesAdvanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li   +8 more
wiley   +1 more source

Bona fides acquirer protection in court practice.

open access: yes, 2018
Problēma: tiesu praksē trūkst vienota īpašuma ieguvēja labticības jēdziena, veidu definējuma un saskaņotu kritēriju ieguvēja labticības konstatēšanai, pastāv pretrunas starp Satversmes tiesas konstatēto īpašnieka tiesību aizsardzības prioritāti ...
Kaprāne, Stella
core  

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

open access: yesAdvanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen   +15 more
wiley   +1 more source

Shakespeare in the Head for Health: A Reality Orientation Option for Alzheimer’s Worriers

open access: yesNonpartisan Education Review, 2009
By way of bona fides: As with many Americans, my own extended family has over the years given me plenty of direct contact with senile dementia, the general label for Alzheimer’s disease.
Robert Oliphant
doaj  

The role of public policy reservation in international contracts [PDF]

open access: yesZbornik Radova: Pravni Fakultet u Novom Sadu, 2018
Among the main roles of public policy in the field of international contracts is its role of the object of protection of the public policy reservation, one of the most important tools of private international law, which enables the forum to refuse ...
Ristić Bojana D.
doaj  

Harmonising Legal Values and uBuntu: The Quest for Social Justice in the South African Common Law of Contract

open access: yesPotchefstroom Electronic Law Journal, 2019
In this article, a comparison is drawn between the role of good faith in the development of the Roman law of contract and the emerging role of ubuntu in the South African common law of contract.
Hanri Magdalena Du Plessis
doaj   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

open access: yesAdvanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen   +7 more
wiley   +1 more source

Legal Pluralism, uBuntu and the Use of Open Norms in the South African Common Law of Contract

open access: yesPotchefstroom Electronic Law Journal, 2019
In this article, a comparison is drawn between the role of good faith in the development of the Roman law of contract and the emerging role of ubuntu in the South African common law of contract.
Hanri Magdalena Du Plessis
doaj   +1 more source

Réflexions sur la bona fides et la mala fides dans la tradition du droit romain

open access: yes, 2018
Good faith has often been discussed in the science of Roman law, from the emergence of fides publica in the Early Republic until the generalisation of good faith in all obliga- tions in the Early Modern continental ius commune. In this article, we stress
Waelkens, Laurent
core   +1 more source

Home - About - Disclaimer - Privacy