Results 171 to 180 of about 787 (249)

Co‐operatives and public policy: A scoping review

open access: yesAnnals of Public and Cooperative Economics, EarlyView.
Abstract We sketch a first‐ever map of the scholarly literature on co‐operatives and public policy from a selection of English‐language studies published since 2000 using a scoping review methodology. We find that while co‐operatives are often framed as solutions to societal problems, few scholars draw on formal public policy theories.
Marc‐André Pigeon   +1 more
wiley   +1 more source

Long‐term outcomes for mechanical failure and revision following primary gender‐affirming penile prosthesis insertion

open access: yesBJU International, EarlyView.
Objectives To evaluate revision surgery for mechanical failure and overall revision rates of inflatable penile prostheses (IPPs) in assigned female‐at‐birth (AFAB) individuals. Patients and Methods This was a retrospective cohort study of all AFAB patients who underwent primary IPP implantation between September 2001 and July 2024.
Wai Gin Lee   +6 more
wiley   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

open access: yesBrain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová   +19 more
wiley   +1 more source

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier   +2 more
wiley   +1 more source

CD93—An emerging vascular target in cancer therapy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira   +3 more
wiley   +1 more source

KYNU in Gastric Cancer Cells Promotes Tumor Progression by Influencing Macrophage Polarization Via PF4

open access: yesCancer Science, EarlyView.
KYNU is upregulated in gastric cancer cells and activates the PI3K/Akt pathway, leading to PF4 secretion. PF4 drives nonclassical macrophage polarization with high expression of S100A8 and MMP7, which promotes tumor proliferation, migration, and invasion while suppressing phagocytosis, thereby accelerating gastric cancer progression.
Xilun Cui   +4 more
wiley   +1 more source

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