Results 151 to 160 of about 89,005 (231)
Reassessing Heidegger on Van Gogh: Artistic Experience as Contextual Displacement
European Journal of Philosophy, EarlyView.Abstract This article offers a novel account of Heidegger's long‐debated discussion of a painting of shoes by Van Gogh in ‘The Origin of the Work of Art’. I argue that the Van Gogh episode is best understood as a carefully staged textual enactment of Heidegger's conception of artistic experience, properly construed.
Andrea Vitangeli
wiley +1 more source
Organisational dehumanisation: Authoritativeness as remedy
European Management Review, EarlyView.Abstract According to orthodoxy, the human relations movement was a watershed in rehumanising scientifically managed workplaces. In the wake of such purported reform, pundits (theorists and practitioners alike) have typically taken for granted that 21st century approaches to workplace superintendence, birthed in the wake of the Hawthorne Studies and ...
Jean‐Etienne Joullié +2 more
wiley +1 more source
Common pathways and outliers in glucose catabolism across Trypanosomatidae
The FEBS Journal, EarlyView.Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes +5 more
wiley +1 more source
The FEBS Journal, EarlyView.This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley +1 more source
A guide to transcriptional cyclin‐dependent kinases in cancer
The FEBS Journal, EarlyView.Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin +2 more
wiley +1 more source
Breaking the ice: multiple origins of ice‐binding/antifreeze proteins
The FEBS Journal, EarlyView.Ice‐binding proteins (IBPs) evolved independently in many organisms during Cenozoic cooling and glaciation. In flounders, α‐helical IBPs evolved from an antiviral protein, while similar IBPs arose independently from different progenitors in three other fish lineages.
Laurie A. Graham, Peter L. Davies
wiley +1 more source
The FEBS Journal, EarlyView.Lipid droplets (LD) act as cellular ‘garbage trucks’ that transport cytosolic protein aggregates to the vacuole for degradation in yeast. Protein aggregates are docked to lipid droplets in a triacylglycerol‐dependent manner, transported through the cytoplasm, and transferred to the insoluble protein deposit (IPOD) at the vacuole.
Christoph Reiter +15 more
wiley +1 more source
Gender Tokenism in Corporate Boardrooms in Europe
Gender, Work &Organization, EarlyView.ABSTRACT We examine the tension between the diversity spillover and tokenism hypotheses using a novel and extensive dataset of nearly 6 million private corporations across 29 European countries from 1986 to 2020. The diversity spillover hypothesis suggests that appointing women to supervisory roles facilitates greater female representation in executive
Hubert Drążkowski, Joanna Tyrowicz
wiley +1 more source
Cutaneous involvement by myeloid leukaemias: challenging cases with important implications
Histopathology, EarlyView.Myeloid leukaemias and precursors involving the skin are often challenging to diagnose with varied and overlapping clinical and histopathologic features. Nonetheless, they are critical for pathologists to recognize and accurately classify. This review discusses the clinical, histopathological and genetic features of myelodysplasia cutis (A) and ...
Alexandra C. Hristov
wiley +1 more source
Insect Molecular Biology, EarlyView.Multi‐species transcriptomics and deep learning identified candidate genes associated with silk and venom production in Bibionomorpha. Venom‐associated genes were enriched in proteases, inhibitors and pore‐forming proteins, whereas silk‐related genes showed chitin‐binding and peritrophin domains. Integrating co‐expression networks, machine learning and
Daniel Kenji Matuo +2 more
wiley +1 more source