Results 161 to 170 of about 1,371 (289)

Revisiting the Association Between Calcium Channel Blockers and Parkinson's Disease in the E3N Cohort

Movement Disorders, EarlyView.
Abstract Background Previous studies on calcium channel blockers (CCBs) and Parkinson's disease (PD) risk reached conflicting conclusions. Objectives We examined the relationship between CCBs and PD in the E3N cohort of French women followed for 15 years (2004–2018), while taking into account the potential for reverse causation.
Emilie Moutard, Agnès Fournier, Émeline Courtois, Fanny Artaud, Pascale Tubert‐Bitter, Emmanuel Roze, Ismaïl Ahmed, Anne C.M. Thiébaut, Alexis Elbaz, Thi Thu Ha Nguyen   +9 more
wiley   +1 more source

Pearls for Starting a Headache Surgery Practice in Academic and Private Practice. [PDF]

JPRAS Open
Saad M, Connor L, Hazewinkel MHJ, Peled ZM, Hagan R, Gfrerer L, Kassis SA.   +6 more
europepmc   +1 more source

Simplifying research access to genomics and health data with Library Cards. [PDF]

Sci Data, 2018
Cabili MN, Carey K, Dyke SOM, Brookes AJ, Fiume M, Jeanson F, Kerry G, Lash A, Sofia H, Spalding D, Tasse AM, Varma S, Pandya R.   +12 more
europepmc   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Generalizing the Gaussian Network Model: Spanning‐Tree Thermodynamics Shows Entropy‐Driven KRAS Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley   +1 more source

FanFAIR: sensitive data sets semi-automatic fairness assessment. [PDF]

BMC Med Inform Decis Mak
Gallese C, Scantamburlo T, Manzoni L, Giannerini S, Nobile MS.   +4 more
europepmc   +1 more source

Phospho-seq: Integrated, multi-modal profiling of intracellular protein dynamics in single cells

, 2023
Blair JD, Hartman A, Zenk F, Dalgarno C, Treutlein B, Satija R.   +5 more
europepmc   +1 more source

Anacardic acid, interleukin-33, and the quest for remyelination. [PDF]

Proc Natl Acad Sci U S A, 2020
Ramanathan M.
europepmc   +1 more source

Greening aviation in era of COVID-19: Towards conceptualizing and operationalizing decarbonization. [PDF]

J Environ Manage, 2023
Amankwah-Amoah J, Debrah Y, Anang S.
europepmc   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source