Results 141 to 150 of about 89,005 (231)

Co‐operatives and public policy: A scoping review

Annals of Public and Cooperative Economics, EarlyView.
Abstract We sketch a first‐ever map of the scholarly literature on co‐operatives and public policy from a selection of English‐language studies published since 2000 using a scoping review methodology. We find that while co‐operatives are often framed as solutions to societal problems, few scholars draw on formal public policy theories.
Marc‐André Pigeon, Hanif Amoozadeh Mahdiraji   +1 more
wiley   +1 more source

Long‐term outcomes for mechanical failure and revision following primary gender‐affirming penile prosthesis insertion

BJU International, EarlyView.
Objectives To evaluate revision surgery for mechanical failure and overall revision rates of inflatable penile prostheses (IPPs) in assigned female‐at‐birth (AFAB) individuals. Patients and Methods This was a retrospective cohort study of all AFAB patients who underwent primary IPP implantation between September 2001 and July 2024.
Wai Gin Lee, Andrea Gobbo, Angelo di Giovanni, Maria Muni' I Sureda, Matilde Braida, Andrew N. Christopher, David J. Ralph   +6 more
wiley   +1 more source

Opposing roles of acid phosphatase 1 (ACP1) and ACP3 in prostate cancer progression

BJU International, EarlyView.
Objectives To evaluate the roles of intracellular acid phosphatase 1 (ACP1) and ACP3 expression as biomarkers of prostate cancer progression through a systematic review and meta‐analysis assessing associations with disease presence, tumour aggressiveness, and patient prognosis.
Alessandra V. de S. Faria, Carmen V. Ferreira‐Halder, Maikel P. Peppelenbosch, Gwenny M. Fuhler   +3 more
wiley   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination‐Mediated c‐Myc Degradation

Cancer Science, EarlyView.
Targeted triggering of SORL1 expression through a novel MPOC delivery system could inhibit ccRCC progression through binding to TRIM22 and further promoting ubiquitination‐mediated C‐MYC degradation, thereby facilitating the inhibition of oxidative phosphorylation through transcriptional repression of ACO2 and IDH2.
Keyi Wang, Wei Song, Qi Bai, Shaoze Shen, Xiao Lu, Chenxuan Su, Shi Yang, Yidi Wang, Yu Xia, Rui Zan, Shuai Jiang, Jianming Guo   +11 more
wiley   +1 more source

CDK4/6 Inhibitors and Curcumin Synergistically Suppress HER2− Breast Cancer via Lethal ROS and Inhibition of Metastasis

Cancer Science, EarlyView.
Schematic illustrating that CDK4/6 inhibitors combined with curcumin induce lethal ROS accumulation by disrupting redox balance, downregulating GPX4, and depleting glutathione, leading to DNA damage and lipid peroxidation. This oxidative stress triggers tumor cell death and suppresses EMT‐driven migration.
Chenyu Wang, Yiqin Zou, Chunyu Chang, Siyue Liu, Xiankun Ke, Liang Hu, Di Wang, Yukang Lu, Shiwen Luo, Sijian Huang, Yilan Hu, Wenqi Yu, Aiping Deng, Ming Yue, Jue Jiang   +14 more
wiley   +1 more source

Improving obesity management: Insights from the ACTION Switzerland survey of people with obesity, physicians and dietitians

Clinical Obesity, Volume 15, Issue 2, April 2025.
PwO, people with obesity. Summary ACTION Switzerland (NCT05232786) examined obesity‐related perceptions, attitudes, behaviours and potential barriers to treatment among people with obesity (PwO) and healthcare professionals (HCPs). In March/April 2022, adult PwO (body mass index ≥30 kg/m2, per self‐reported height/weight) and physicians/certified ...
Dominique Durrer, Patrick Pasi, Ralph Peterli, Doris Fischer‐Taeschler, Gabriela Fontana, Gionata Cavadini, Philipp A. Gerber   +6 more
wiley   +1 more source

Associations between prior wasting malnutrition and indices of insulin secretion and sensitivity among six cohorts from Asia and Africa: The SAMPA study

Diabetic Medicine, EarlyView.
Abstract Aims The role of prior wasting malnutrition (PM) in determining insulin sensitivity and secretion in low‐ and middle‐income countries (LMICs) remains unclear. We investigated associations of insulin indices with PM and whether these were modified by current body mass index (BMI).
Sharon E. Cox, Sana Ahmed, Dixi Paglinawan Modoc, Riddhi Dasgupta, Christina Christoffersen, Molly Chisenga, Julius Patrick Ferrer, Ruth Frikke‐Schmidt, Rikke Krogh‐Madsen, Belinda Kweka, Nanette Lee, Evangelista Malindisa, Mizinga J. Tembo, Patrick Ngoya, Dorothea Nitsch, Daniel Faurholt‐Jepsen, George PrayGod, Geeta Trilok‐Kumar, Suzanne Filteau, James A. M. Shaw   +19 more
wiley   +1 more source

Longitudinal Associations of Changes in Body Mass Index and Waist‐to‐Height Ratio With Cardiometabolic Risk Factors: Sex‐Specific Analyses in UK Biobank

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To examine associations of within‐person changes in body mass index (BMI) and waist‐to‐height ratio (WHtR) with cardiometabolic outcomes, characterise dose–response non‐linearity and investigate effect modification by sex. Materials and Methods In this observational UK Biobank cohort, participants had repeated anthropometric and ...
Ayat Musa, Mark Woodward, Naveed Sattar, Rona J. Strawbridge, Jill P. Pell, Qiaoling Liu, Jennifer S. Lees, Patrick B. Mark, Jack Beazer, Malek Ahmad, Jason M. R. Gill, Lyn D. Ferguson, Paul Welsh   +12 more
wiley   +1 more source