Results 111 to 120 of about 4,430,580 (382)
Bond Energies and the Interactions between Next-Nearest Neighbors. I. Saturated Hydrocarbons, Diamond, Sulfanes, S8, and Organic Sulfur Compounds [PDF]
, 1959 Thomas L. Allen
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The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Stretching Force Constant of the Carbonyl Bond in Unconjugated Ketones [PDF]
, 1956 J. O. Halford
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FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Health Services InsightsBackground: Efficient musculoskeletal care is important for health services and society. Surgical conversion rates are a common measure of efficiency, yet normal values and the impact of referrer type are unclear.
Darryn Marks +5 more
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Temperature effects on bond between concrete and reinforcing steel [PDF]
Zbornik Radova Građevinskog Fakulteta, 2014 Bond behaviour between concrete and reinforcing bars was observed under elevated temperatures. Five different concrete compositions were used. Hundred five pull-out specimens (Ø120 mm, 100 mm) were prepared. After removing the specimens from the formwork,
Lublóy Éva, György Balázs L.
doaj
The Nature of the Chemical Bond. VII. The Calculation of Resonance Energy in Conjugated Systems [PDF]
, 1933 Linus Pauling, Jes Sherman
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Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source