Results 51 to 60 of about 199,861 (265)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Steel and concrete bond stress: a contribution to the study of APULOT tests using concrete with rubber addition

Revista IBRACON de Estruturas e Materiais
The bond stress between steel and concrete is the essential condition to the good behaviour of reinforced concrete structures. To preview the use of concrete with waste incorporation for structural aims, the verification of its quality control is ...
A. E. P. G. De Avila Jacintho, L. L. Pimentel, M. P. Barbosa, P. S. P. Fontanini   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Uniaxial Bond Stress-Slip Relationship of Reinforcing Bars in Concrete

Advances in Materials Science and Engineering, 2012
This paper documents a study carried out on the estimation of the bond stress-slip relationship for reinforced concrete members under axial tension loading.
Sungnam Hong, Sun-Kyu Park
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Comportamento de emenda por traspasse de barras comprimidas em contato e separadas

Revista IBRACON de Estruturas e Materiais
Neste trabalho é resumido um estudo experimental sobre o comportamento de emendas por traspasse de barras comprimidas em pilares de concreto armado, com o objetivo de investigar a influência da distância entre as barras emendadas sobre o comportamento da
C. B. Quintana, G. B. Guimarães, L. D. Shehata   +2 more
doaj   +1 more source

Bonding Strength of Alumina Joint Bonded under the Alternating Stress

Journal of the Ceramic Society of Japan, 1993
Two alumina cylinders of commercial purity, 10mm high and 10mm in diameter were bonded together using an aluminum film. In addition to the normal bonding process, bonding under alternating bonding pressure was performed, and the effect of the alternating applied stress on the bonding strength of the joint was investigated based upon the statistical ...
SASAKI, Kazunori, MOTOIE, Katsuhiko, KAWASAKI, Tadashi   +2 more
openaire   +2 more sources