Results 221 to 230 of about 606,113 (264)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

The impact of garlic and its active metabolites on degenerative musculoskeletal diseases. [PDF]

Front Pharmacol
Cheng N, Zhao J, Feng C, Li Z, Song Y, Sun X.   +5 more
europepmc   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

E3 ubiquitin ligases in bone homeostasis: from regulatory mechanisms to skeletal diseases and therapeutic targeting. [PDF]

Front Cell Dev Biol
Zhao Y, Cao N, Yang W, Wang Y, Wang W.
europepmc   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Multi-omics reveals circadian regulation of bone homeostasis by gut microbiota metabolites: mechanisms and chronotherapeutic implications. [PDF]

Front Immunol
Liu M, Gong J, Liu Y, Yu J, Hu Z, Liu Z.
europepmc   +1 more source

Data Sheet 1_Computational simulations of endocrine bone diseases related to pathological glandular PTH secretion using a multi-scale bone cell population model.pdf

Corinna Modiz (22346065), Natalia M. Castoldi (22346068), Stefan Scheiner (5736614), Javier Martínez-Reina (849042), Jose L. Calvo-Gallego (22346071), Vittorio Sansalone (5997005), Saulo Martelli (2891018), Peter Pivonka (197374)   +7 more
openalex   +1 more source

Retrotransposons in Bone and Joint Diseases. [PDF]

FASEB Bioadv
Liu Y, Jang HJ, Yang T.
europepmc   +1 more source

Bilateral Transient Osteoporosis of the Hip in Pregnancy: Diagnostic Challenges, MRI-Based Approach, and Multidisciplinary Management. [PDF]

Diseases
Zubor P, Lind KO, Visnovsky J, Zuborova P, Grimnes G, Kjærvik C.   +5 more
europepmc   +1 more source

Bibliometric and visualized analysis of metal‒organic frameworks in bone tissue engineering and bone diseases. [PDF]

Discov Nano
Xia K, Yu L, Qin J, Zhu M, Fan M, Qian W.   +5 more
europepmc   +1 more source