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Immunosenescence and Bone Homeostasis: From Mechanisms of Homeostasis Disruption to Therapeutic Opportunities in Age-Related Skeletal Disorders. [PDF]
Int J Mol SciJiang F, Dong B, Wang Y, Xiong Y.
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RNA interference and its application in bone-related diseases
Biochemical and Biophysical Research Communications, 2007RNA interference (RNAi) is the most exciting insight in biology in past decades, which provided new perspectives into the genome-wide surveys of gene function by targeted degradation of mRNA with the introduction of small interfering RNAs (siRNAs) or small hairpin RNAs (shRNAs) in a large variety of organisms, and turned out to be a more efficient and ...
Ya Lin, Li +3 more
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Nanoscale materials-based platforms for the treatment of bone-related diseases
Matter, 2021Summary Owing to the high density of bone tissue and the complex and highly hierarchical structure, drugs used for the treatment of bone-related diseases are often not effectively concentrated at the site of the lesion. Generally, the therapeutic effect is unsatisfactory, and the long-term use of drugs causes adverse effects.
Xiaodi Zhang +10 more
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The role of the fibroblast growth factor family in bone‐related diseases
Chemical Biology & Drug Design, 2019AbstractFibroblast growth factor (FGF) family members are important regulators of cell growth, proliferation, differentiation, and regeneration. The abnormal expression of certain FGF family members can cause skeletal diseases, including achondroplasia, craniosynostosis syndrome, osteoarthritis, and Kashin–Beck disease. Accumulating evidence shows that
Jicheng Wang +3 more
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Recent advances in functional nanostructured materials for bone-related diseases
Journal of Materials Chemistry B, 2019This article reviews the recent advances in the development of nanostructured materials for bone-related diseases such as osteoporosis and osteoarthritis.
Anqi Li, Jing Xie, Jianshu Li
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[Research progress of necroptosis on bone related diseases].
Zhongguo gu shang = China journal of orthopaedics and traumatology, 2021As a new type of cell death, necroptosis is initiated by tumor necrosis factor receptor 1(TNFR1), and then activated receptor-interacting protein kinase 1(RIP1) and receptor-interacting protein kinase 3 (RIP3), following by the activation of mixed lineage kinase domain-like protein(MLKL) to deliver cell death signal.
Zu-Ge, Yang +5 more
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The role of Notch signaling pathway in metabolic bone diseases
Biochemical Pharmacology, 2023Yongguang Gao
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