Results 121 to 130 of about 2,426,310 (311)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

An experimental and computational investigation of bone cement residual stresses [PDF]

, 2006
Hip arthroplasty is a common orthopaedic procedure with considerable success in alleviating hip joint pain and disability. To transfer loads from the prosthesis to the contiguous bone, self-curing polymethyl methacrylate, often referred to as bone cement,
Hingston, John A.
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Integrasi Nilai Budaya dalam Sistem Irigasi Tradisional Pabbage Wae sebagai Mekanisme Resolusi Konflik Air

Jurnal Ilmu Sosial dan Humaniora
Sistem irigasi tradisional Pabbage Wae masyarakat Bugis tidak hanya berfungsi sebagai teknik distribusi air, tetapi sebagai pranata sosial-budaya dalam pengelolaan sumber daya agraris.
Sartika Sari Dewi, Andi Muhammad Irfan Taufan Asfar, Andi Muhamad Iqbal Akbar Asfar, Muhlis Muhlis, Andi Nurannisa, Wiwi Damayanti   +5 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Influence of riverine outputs on sandy beaches of Higuerote, central coast of Venezuela Influencia de aportes fluviales en playas arenosas de Higuerote, costa central de Venezuela

Latin American Journal of Aquatic Research, 2011
The influence of riverine outputs from the Tuy River on the coastal processes of near sandy beaches was assessed by measuring the physical and chemical characteristics of water and sediment samples at eight sites along the north central Venezuelan coast ...
Antonio Herrera, David Bone
doaj  

Bone mineral status in immigrant Indo-Asian women

, 2004
Background: Indo-Asian immigrants are known to be at high risk of metabolic bone disease, but the prevalence of osteoporosis in this population is unknown.Aim: To compare the bone mineral at the lumbar spine and femoral neck of Indo-Asian immigrant women
Mehta, G, Walker-Bone, K., Mehta, G., Walker-Bone, K, Cooper, C., Petley, G, Taylor, P, Taylor, P., Petley, G., Dennison, E., Cooper, Cyrus, Cooper, C, Dennison, E   +12 more
core   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Growth hormone induces bone morphogenetic proteins and bone-related proteins in the developing rat periodontium

, 2001
The hypothesis that growth hormone (GH) up-regulates the expression of enzymes, matrix proteins, and differentiation markers involved in mineralization of tooth and bone matrices was tested by the treatment of Lewis dwarf rats with GH over 5 days.
Bartold, P. Mark, P. Mark Bartold, Huika Li, Waters, M., Xiao, Y., Young, William G., Li, Huika, Xiao, Yin, Waters, Michael John, Michael J. Waters, Bartold, P., Young, W., Yin Xiao, Li, H., William G. Young   +14 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source