Results 81 to 90 of about 7,204,437 (249)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Bone health in children with inflammatory bowel disease: adjusting for bone age

, 2009
Objectives: Clinical results of bone mineral density for children with inflammatory bowel disease are commonly reported using reference data for chronological age. It is known that these children, particularly those with Crohn disease, experience delayed
Cleghorn, Geoffrey J., Geoffrey D. Withers, Connor, F. L., Withers, G. D., Hill, R. J., Lewindon, P. J., Rebecca J. Hill, Brookes, D. S. K., Ee, L. C., Frances L. Connor, Peter S.W. Davies, Davies, P. S. W., Denise S.K. Brookes, Looi C. Ee, Peter J. Lewindon, Geoffrey J. Cleghorn, Peter SW Davies, Peter J Lewindon, Frances L Connor, Geoffrey D Withers, Looi C Ee, Rebecca J Hill, Denise SK Brookes, Geoffrey J Cleghorn   +23 more
core   +1 more source

Age-stratified bone mineral density and fracture risk assessment score status.

, 2023
Age-stratified bone mineral density and fracture risk assessment score status.
Nipith Charoenngam (6420326), Dueanchonnee Sribenjalak (14564132), Chatlert Pongchaiyakul (5465432), Piyachat Chanidkul (14564129)   +3 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Research Status and Application Prospect of Bone Age Assessment by Ultrasonography

Xiehe Yixue Zazhi
Bone age, the most commonly used and effective indicator for understanding children's growth and development, plays an important role in the diagnosis and efficacy evaluation of various growth and development disorders.
ZHAO Zeqing, PAN Hui, ZHANG Li, WANG Fengdan, CHEN Shi, YANG Xiao, LI Jianchu   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Bone microstructure at the distal tibia provides a strength advantage to males in late puberty: An HR‐pQCT study

, 2010
Bone is a complex structure with many levels of organization. Advanced imaging tools such as high‐resolution (HR) peripheral quantitative computed tomography (pQCT) provide the opportunity to investigate how components of bone microstructure differ ...

core   +1 more source

Determining ‘Age at Death’ for Forensic Purposes using Human Bone by a Laboratory-based Analytical Method [PDF]

, 2013
Determination of age-at-death (AAD) is an important and frequent requirement in contemporary forensic science and in the reconstruction of past populations and societies from their remains.
Giles, R., Zioupos, Peter, Zioupos, P., Williams, A., Christodoulou, G., Williams, Anna   +5 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source