Results 71 to 80 of about 1,019,186 (310)

Determining ‘Age at Death’ for Forensic Purposes using Human Bone by a Laboratory-based Analytical Method

, 2013
Determination of age-at-death (AAD) is an important and frequent requirement in contemporary forensic science and in the reconstruction of past populations and societies from their remains.
Giles, R., Zioupos, Peter, Zioupos, P., Williams, A., Christodoulou, G., Williams, Anna   +5 more
core   +1 more source

Bone Age Assessment Empowered with Deep Learning: A Survey, Open Research Challenges and Future Directions

Diagnostics, 2020
Deep learning is a quite useful and proliferating technique of machine learning. Various applications, such as medical images analysis, medical images processing, text understanding, and speech recognition, have been using deep learning, and it has been ...
Muhammad Waqas Nadeem, Hock Guan Goh, Abid Ali, Muzammil Hussain, Muhammad Adnan Khan, Vasaki a/p Ponnusamy   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Patterns in the modification of animal and human bones in Iron Age Wessex: revisiting the excarnation debate [PDF]

, 2008
Social practices concerning the treatment of human and animal remains in the Iron Age have long been a focus of debate in archaeological literature. The absence of evidence of a formal burial rite and the regular retrieval of human remains from ‘special’
Madgwick, Richard
core  

Upper Limb Muscle–Bone Asymmetries and Bone Adaptation in Elite Youth Tennis Players [PDF]

, 2013
Introduction: The study of tennis players allows the nonracket arm to act as an internal control for the exercising racket arm. In addition, the study of the upper limbs removes the influence of gravitational loading, allowing the examination of the ...
Degens H., Ireland A., Cooke, K, Maden-Wilkinson T., McPhee J., Degens, Hans, Maden-Wilkinson, Thomas, Rittweger J., Degens, H., Mcphee, J, Degens, H, Ireland, A., Narici, Marco, Ireland, Alex, McPhee, Jamie, Rittweger, J., Rittweger, Jörn, Ireland, A, Rittweger, J, Maden-Wilkinson, Tom, Narici, M, Narici, M., Cooke, Karl, Cooke, K., Maden-Wilkinson, T, Narici M., McPhee, J., Cooke K.   +27 more
core   +1 more source

Aging mechanisms in bone

BoneKEy Reports, 2012
Advancing age and loss of bone mass and strength are closely linked. Elevated osteoblast and osteocyte apoptosis and decreased osteoblast number characterize the age-related skeletal changes in humans and rodents. Similar to other tissues, oxidative stress increases in bone with age.
openaire   +3 more sources

Familial, constitutional, and combined idiopathic short stature: longitudinal growth patterns and pubertal effects

Frontiers in Pediatrics
BackgroundPathological causes account for approximately 15%–20% of short-stature cases, whereas about 80% of short-statured children have no identifiable underlying etiology and are classified as idiopathic short stature (ISS).
Erkut Gürlek, Sirmen Kızılcan Çetin, Elif Özsu, Zehra Aycan, Merih Berberoğlu, Zeynep Şıklar   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Automatic Bone Age Determination in Adult Height Prediction for Girls with Early Variants Puberty and Precocious Puberty [PDF]

J Clin Res Pediatr Endocrinol
Objective: In cases of precocious puberty, the determination of bone age (BA) is usually performed by clinicians using the Greulich-Pyle (GP) atlas, and there can be significant variation between assessors.
Yiğit MH, Eviz E, Hatun Ş, Yeşiltepe Mutlu G.   +3 more
europepmc   +2 more sources

Inhibition of CaMKK2 reverses age-associated decline in bone mass

, 2015
Decline in bone formation is a major contributing factor to the loss of bone mass associated with aging. We previously showed that the genetic ablation of the tissue-restricted and multifunctional Ca(2+)/calmodulin (CaM)-dependent protein kinase kinase 2
Yang, Chang, Sankar, Uma, Cary, Rachel L., Novack, Deborah V., Voor, Michael J., Pritchard, Zachary J.   +5 more
core   +1 more source