Results 41 to 50 of about 194,946 (266)

Poster 107: The Use of Coacervate Sustained Release System to Identify the Most Potent BMP for Bone Regeneration

Orthopaedic Journal of Sports Medicine, 2022
Objectives: Bone morphogenetic proteins (BMPs) belong to the transforming growth factor superfamily that were first discovered by Marshall Urist. There are 14 BMPs identified to date, each with distinct and versatile functional roles.
Johnny Huard, Mintai Hwang, Matthieu Huard, Johnny Huard, Joseph Ruzbarsky MD, Sudheer Ravuri, Yadong Wang, Johnny Huard, Xueqin Gao MD   +8 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Influence of the geometry of nanostructured hydroxyapatite and alginate composites in the initial phase of bone repair [PDF]

Acta Cirúrgica Brasileira, 2019
Purpose: To analyze, histomorphologically, the influence of the geometry of nanostructured hydroxyapatite and alginate (HAn/Alg) composites in the initial phase of the bone repair.
George Gonçalves dos Santos, Luisa Queiroz Vasconcelos, Suelen Cristina da Silva Poy, Renata dos Santos Almeida, Aryon de Almeida Barbosa Júnior, Silvia Rachel de Albuquerque Santos, Alexandre Malta Rossi, Fúlvio Borges Miguel, Fabiana Paim Rosa   +8 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Impact of bone defect morphology on the outcome of reconstructive treatment of peri-implantitis

International Journal of Implant Dentistry, 2020
Objectives To assess if (I) the alveolar bone defect configuration at dental implants diagnosed with peri-implantitis is related to clinical parameters at the time of surgical intervention and if (II) the outcome of surgical intervention of peri ...
Ahmad Aghazadeh, Rutger G. Persson, Stefan Renvert   +2 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Preoperative pars defect length predicts bone union after direct repair for lumbar spondylolysis using the modified smiley face rod technique: a retrospective cohort study [PDF]

Asian Spine Journal
Study Design A retrospective cohort study. Purpose To determine whether the preoperative pars defect length predicts bone union following the modified smiley face rod (mSFR) technique for lumbar spondylolysis and to identify a threshold for clinical ...
Shotaro Teruya, Shun Okuwaki, Hisanori Gamada, Toru Funayama, Masaki Tatsumura   +4 more
doaj   +1 more source

Tapered stem geometry provides superior initial fixation stability to cylindrical stem geometry in the setting of severe bone loss: A finite element analysis

Engineering Reports, 2020
Initial stability of cementless stems used in total hip arthroplasty (THA) is critical for subsequent osseointegration at the bone/implant interface. In the setting of revision THA, there is frequently less intact femoral bone available for fixation of ...
Victor Kosmopoulos, Robert D. Russell, Danieli C. Rodrigues, Gabriella Bucci, Michael H. Huo   +4 more
doaj   +1 more source