Results 31 to 40 of about 1,877,704 (275)

Role of peripheral quantitative computed tomography in identifying disuse osteoporosis in paraplegia [PDF]

, 2009
Objective: Disuse osteoporosis is a major long-term health consequence of spinal cord injury (SCI) that still needs to be addressed. Its management in SCI should begin with accurate diagnosis, followed by targeted treatments in the most vulnerable ...
Coupaud, Sylvie, Allan, David, Allan, D.B., McLean, Alan, Coupaud, S., McLean, A.N.   +5 more
core   +1 more source

Does lower-body BMD develop at the expense of upper-body BMD in female runners? [PDF]

, 2003
PURPOSE: Evidence suggests that exercise plays an important role in stimulating site-specific bone mineral density (BMD). However, what is less well understood is how these benefits dissipate throughout the body.
Nevill, AM, Holder, Roger, Simpson, D., Holder, Roger L., Burrows, Melonie, Simpson, David, Nevill, Alan M., Bird, Steve, Burrows, M   +8 more
core   +1 more source

Evaluation of bone mineral density and biochemical markers in pediatric patients with phenylketonuria

Molecular Genetics and Metabolism Reports
Objectives: Phenylketonuria is a hereditary condition caused by the deficiency of the enzyme phenylalanine hydroxylase, leading to abnormal phenylalanine metabolism.
Akram Ehsasat Vatan, M.D., Amin Mottaghizade Gargari, M.D., Arian Haghtalab, M.D., Nima Ebrahimpour Seraydar, M.D.   +3 more
doaj   +1 more source

Assessing bone health in children and adolescents

Indian Journal of Endocrinology and Metabolism, 2012
During normal childhood and adolescence, the skeleton undergoes tremendous change. Utilizing the processes of modeling and remodeling, the skeleton acquires its adult configuration and ultimately achieves peak bone mass.
Michael A Levine
doaj   +1 more source

Clinical factors associated with trabecular bone score.

, 2013
Dual-energy X-ray absorptiometry (DXA) measurement of bone mineral density (BMD) is the reference standard for diagnosing osteoporosis but does not directly reflect deterioration in bone microarchitecture.
Hans, D., Leslie, W.D., Manitoba Bone Density, Program, Krieg, M.A.   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Bone geometry and volumetric bone mineral density in girls with Turner syndrome of different pubertal stages

, 2010
Objective An increased rate of fractures has been reported in patients with Turner syndrome (TS). We aimed to assess bone geometry and volumetric bone mineral density (vBMD) at the radius in girls with TS and to evaluate the relationships between bone
Kolouskova, Stanislava, Rittweger, Jörn, Soucek, Ondrej, Jan Lebl, Zdenek Sumnik, Snajderova, Marta, Ondrej Cinek, Zdenek Hlavka, Stanislava Kolouskova, Lebl, Jan, Marta Snajderova, Rocek, Miloslav, Cinek, Ondrej, Joern Rittweger, Miloslav Rocek, Ondrej Soucek, Sumnik, Zdenek   +16 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Tibial dyschondroplasia and bone mineral density

Brazilian Journal of Poultry Science, 2004
This study was carried out at Faculdade de Medicina Veterinária e Zootecnia, UNESP, Botucatu-SP, Brazil. The aim was to establish the normal values of bone mineral density (BMD) expressed in millimeters of aluminum in the tibia of broiler chickens using ...
Paz ICL Almeida, AA Mendes, TS Takita, LC Vulcano, PC Guerra, FS Wescheler, RG Garcia   +6 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source