Results 41 to 50 of about 1,877,704 (275)

Application of Osteorisk to postmenopausal patients with osteoporosis

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Identification of women at risk of bone fracture is becoming less dependent on evaluating bone mineral density through placing greater value on clinical risk factors.
Marcelo Luis Steiner, César Eduardo Fernandes, Rodolfo Strufaldi, Everaldo Cunha Porto, Luciano de Melo Pompei, Sérgio Peixoto   +5 more
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Hubungan Aktifitas Fisik dengan Kekuatan Tulang Pada Pasien Menopause di Rumah Sakit Olahraga Nasional Kemenpora Tahun 2017

Saintika Medika, 2018
HUBUNGAN ANTARA AKTIFITAS FISIK DENGAN KEKUATAN TULANG PADA PASIEN MENOPAUSE DI RUMAH SAKIT OLAHRAGA NASIONAL KEMENPORA TAHUN 2017   Laras Bani Waseso   ABSTRAK   Osteoporosis tiga kali lebih sering terjadi pada perempuan menopause dan kurang aktifitas
Laras Bani Waseso
doaj   +1 more source

COMPARATIVE ANALYSIS OF QUANTITATIVE COMPUTED TOMOGRAPHY DATA AND HISTOLOGICAL FINDINGS IN PATIENTS WITH GIANT CELL BONE TUMOR TREATED WITH DENOSUMAB

Сибирский онкологический журнал, 2021
Background. Giant cell tumor of bone (GCTB) is a common benign lesion accounting for 4–9.5 % of all primary bone tumors. Although surgery is considered the method of choice in the treatment of GCT, however, denosumab, a genetically engineered drug with a
S. A. Tabakaev, I. G. Frolova, I. I. Anisenya, N. V. Vasilyev, A. V. Bogoutdinova, P. K. Sitnikov   +5 more
doaj   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Bone Mineral Density in 10 to75 Year-Old Iranian Healthy Women: Population Base Study [PDF]

Iranian Journal of Public Health, 2004
Osteoporosis is a major public health problem in Iran. Bone densitometry is used to diagnose osteopenia and osteoporosis and if necessary, prevent bone fractures, especially that of femoral neck. Bone density is related to several factors including race,
M Pajouhi, Zh Maghbooli, S Mortaz Hejri, AA Keshtkar, M Saberi, B Larijani   +5 more
doaj   +2 more sources

Impact of degenerative radiographic abnormalities and vertebral fractures on spinal bone density of women with osteoporosis

São Paulo Medical Journal, 2002
CONTEXT: Measurements of bone density taken by dual-energy x-ray absorptiometry are the most accurate procedure for the diagnosis of osteoporosis.
Lúcia Costa Paiva, Silvana Filardi, Aarão Mendes Pinto-Neto, Adil Samara, João Francisco Marques Neto   +4 more
doaj   +1 more source