Results 91 to 100 of about 9,752 (200)

Assessment of the efficacy and safety of anti-sclerostin antibody therapy for osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Front Endocrinol (Lausanne)
Chen L, Wang Q, Gu M.
europepmc   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Effect of hyaluronic acid on the prevention of medication-related osteonecrosis of the jaw in a bisphosphonate-treated rat model. [PDF]

BMC Oral Health
Gachayev K, Şimşek Kaya G, Kaya M, Özalp Ö, Altunay B, Toru HS.   +5 more
europepmc   +1 more source

Move beyond free radical theory of aging

iMetaOmics, EarlyView.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

Early Postmenopausal Fragility Fractures and Elevated IgE: Two Cases Suggesting Hyper-IgE Syndrome and a Novel Adverse Reaction to Romosozumab. [PDF]

Calcif Tissue Int
Collins L, Ebeling PR.
europepmc   +1 more source

Oral proton‐reprogrammed nanomedicine to break the inflammatory bowel disease‐Clostridium difficile infection vicious cycle

iMeta, EarlyView.
Research on the mechanism of OPR restoring intestinal epithelial cell (IEC) structure and function in inflammatory bowel disease (IBD) treatment. (A) Schematic diagram of OPR structure and the rate of GP release under different conditions. (B) Schematic diagram of OPR targeting IBD colonic lesions through charge interaction.
Wensheng Chen, Yuntao Zhang, Jue Wang, Yiming Li, Hao Wu, Qiong Huang, Wei Wu, Kelong Ai   +7 more
wiley   +1 more source

Two-year outcomes of denosumab treatment for osteoporosis comparing the effects of calcium and vitamin D supplementation. [PDF]

Sci Rep
Cho YH, Byun SE, Lee HH.
europepmc   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Comparative Effects of Minodronate and Alendronate on Low Back Pain in Postmenopausal Osteoporosis and Age Influence: A Head-to-Head, Randomized Clinical Trial. [PDF]

Clin Interv Aging
Wang H, Liu H, Huang J, Meng X, Wang W, Xiao W, Liu D, Tao L, Song C.   +8 more
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source