Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. [PDF]
, 2010 BackgroundThe activation of signal transducer and activator of transcription 3 (Stat3) pathway correlates with tumor growth, survival, drug resistance and poor prognosis in osteosarcoma.
Choy, Edwin +6 more
core +4 more sources
Advanced NanoBiomed Research, EarlyView.Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo +2 more
wiley +1 more source
Computational simulation of bone remodelling post reverse total shoulder arthroplasty [PDF]
arXiv, 2017 Bone is a living material. It adapts, in an optimal sense, to loading by changing its density and trabeculae architecture - a process termed remodelling. Implanted orthopaedic devices can significantly alter the loading on the surrounding bone, which can have a detrimental impact on bone ingrowth that is critical to ensure secure implant fixation.
arxiv
CAST – City analysis simulation tool: an integrated model of land use, population, transport and economics [PDF]
, 2005 The paper reports on research into city modelling based on principles of Science of Complexity. It focuses on integration of major processes in cities, such as economics, land use, transport and population movement.
Alwan, Zaid +2 more
core
Baixa massa óssea em crianças e adolescentes [PDF]
, 2006 Osteoporosis is a disease characterized by low bone mass and micro architectural alterations of bone tissue leading to enhanced bone fragility and increased fracture risk.
Borges, João Lindolfo C. +1 more
core +3 more sources
let-7 microRNAs regulate microglial function and suppress glioma growth through Toll-like receptor 7 [PDF]
, 2019 Microglia express Toll-like receptors (TLRs) that sense pathogen- and host-derived factors, including single-stranded RNA. In the brain, let-7 microRNA (miRNA) family members are abundantly expressed, and some have recently been shown to serve as TLR7 ...
Buonfiglioli, Alice +2 more
core +1 more source
2012 update of French guidelines for the pharmacological treatment of postmenopausal osteoporosis [PDF]
, 2012 OBJECTIVES: To update the evidence-based position statement published by the French National Authority for Health (HAS) in 2006 regarding the pharmacological treatment of postmenopausal osteoporosis, under the auspices of the French Society for ...
B. Cortet +19 more
core +3 more sources
Distribution Principle of Bone Tissue [PDF]
arXiv, 2009 Using the analytic and experimental techniques we present an exploratory study of the mass distribution features of the high coincidence of centre of mass of heterogeneous bone tissue in vivo and its centroid of geometry position. A geometric concept of the average distribution radius of bone issue is proposed and functional relation of this geometric ...
arxiv
The recombinant cysteine proteinase B (CPB) from Leishmania braziliensis and its domains: promising antigens for serodiagnosis of cutaneous and visceral leishmaniasis in dogs. [PDF]
, 2019 Leishmaniasis represents a group of parasitic diseases caused by a protozoan of the genus Leishmania and is widely distributed in tropical and subtropical regions.
Basombrío, Manuel Alberto +10 more
core +1 more source
Disparity of turbinal bones in placental mammals
The Anatomical Record, EarlyView.Abstract Turbinals are key bony elements of the mammalian nasal cavity, involved in heat and moisture conservation as well as olfaction. While turbinals are well known in some groups, their diversity is poorly understood at the scale of placental mammals, which span 21 orders.
Quentin Martinez +11 more
wiley +1 more source