Results 121 to 130 of about 55,987 (284)

Orchestration of Skin Pathology in Cutaneous Lupus Erythematosus by HLA Class I Down‐Regulated Senescent Epidermal Basal Cells

Arthritis &Rheumatology, EarlyView.
Objective This study investigates the role of senescent epidermal basal cells in cutaneous lupus erythematosus (CLE) pathogenesis using skin samples from patients with CLE and a mouse model of systemic lupus erythematosus (SLE). Methods Cellular senescence profiling used datasets from the NCBI GEO database and Accelerating Medicines Partnership (AMP ...
Sena Yamamoto, Yuki Saito, Tsukasa Sato, Seina Nakano, Dain Kasseki, Ayaka Nagao, Norihiro Miura, Kentaro Nagaoka, Arisa Kita, Maki Miyajima, Shogo Ijima, Koji Taniguchi, Atsushi Niida, Takako S. Chikenji   +13 more
wiley   +1 more source

Monocyte‐Derived Macrophages‐Synovial Fibroblasts Crosstalk Unravels Oncostatin Signaling Network as a Driver of Synovitis in Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis (OA) is a debilitating joint disease that is characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet, Olivier Bortolotti, Léa Marineche, Nicole Hannemann, Manon Chambon, Yaël Glasson, Anne‐Sophie Dumé, Julien De Lima, Maud Fournial, Dylan Touchet, Dany Séverac, Felicia Leccia, Christophe Duperray, Henri‐Alexandre Michaud, Farida Djouad, Benoît Le Goff, Frédéric Blanchard, Florence Apparailly, Gabriel Courties   +18 more
wiley   +1 more source

Neck‐vein thrombosis during spaceflight

British Journal of Clinical Pharmacology, EarlyView.
Spaceflight imposes unique environmental challenges, including weightlessness, increased radiation exposure and confinement, which can lead to unexpected health effects. One such example is neck‐vein thrombosis, a condition rarely seen on Earth without predisposing factors such as venous catheters or infections.
Ulrich Limper, Jens Jordan
wiley   +1 more source

Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents.

Journal of Clinical Endocrinology and Metabolism, 2002
M. Hochberg, S. Greenspan, R. Wasnich, P. Miller, D. Thompson, P. Ross   +5 more
semanticscholar   +1 more source

Advances in radiopharmaceuticals for cancer radiotheranostics: CCK2R targeting as a paradigm for translational innovation

Cancer Communications, EarlyView.
Abstract Radiopharmaceuticals are reshaping the landscape of cancer therapy, offering a unique theranostic advantage that is becoming increasingly central to precision medicine. By labeling the same molecular scaffold with different radionuclides, these agents enable seamless integration of diagnostic imaging and targeted therapy.
Jing Li, Xuejun Wen, Rebeka Rita Reszegi, Hemavarshini Kamalrhaj, Wolfgang J. Parak, Xiaoyuan Chen, Jingjing Zhang   +6 more
wiley   +1 more source

Antifracture efficacy of antiresorptive agents are related to changes in bone density.

Journal of Clinical Endocrinology and Metabolism, 2000
R. Wasnich, P. Miller
semanticscholar   +1 more source

AGO Recommendations for Diagnosis and Treatment of Patients with Early and Metastatic Breast Cancer: Update 2012 [PDF]

, 2011
Harbeck, Nadia, Scharl, Anton, Thomssen, Christoph   +2 more
core   +2 more sources

Study on the Screening of Anti‐Osteoporosis Components in Processed Epimedium‐Based on Spectrum‐Effect Analysis

Chemistry &Biodiversity, EarlyView.
ABSTRACT Epimedium (EP) is a traditional Chinese medicine that has been used to treat osteoporosis for several years, but its mechanism of action is unclear. We used ultrahigh‐performance liquid chromatography coupled with triple–quadrupole mass spectrometry (UPLC–QQQ–MS/MS) to detect the components of raw and processed EP samples.
Jinling Liang, Jia Liu, Weixia Sun, Pan Li, Huaizhu Sun, Wenxuan Cao, Yulin Dai, Tianyang Xu, Peng Yu   +8 more
wiley   +1 more source

Bisphosphonate Use in Acute Spinal Cord Injury: A Focused Systematic Review on Zoledronic Acid. [PDF]

Cureus
Mun S, Chalasani R, Van de Vel G, Shukla PS, Zia SUD, Mohammed L.   +5 more
europepmc   +1 more source

Fungal Biodiversity From the Atlantic Forest With Bioactive Metabolites Against Cutaneous Leishmaniasis

Chemistry &Biodiversity, EarlyView.
ABSTRACT Biodiversity offers a rich source of bioactive compounds for drug discovery. We isolated Aspergillus fumigatus from compost in the Atlantic Forest and found its extract active against Leishmania (Leishmania) amazonensis. Two crude extracts, I06 and I75, were selected for further study.
Juliana Cristina Pereira Calado, Marina Valente Navarro, Alison Felipe Alencar Chaves, Isis Casula, Patricia Locosque Ramos, João Batista da Cruz, Anderson Messias Rodrigues, Keith Dayane Leite Lira, Fernando Luiz Affonso Fonseca, Patricia Xander, Suzan Pantaroto de Vasconcellos, Wagner Luiz Batista   +11 more
wiley   +1 more source