Results 31 to 40 of about 1,007,173 (265)

Growth and Bone Development

, 2008
Osteoporosis is a major cause of morbidity and mortality through its association with age-related fractures. Although most effort in fracture prevention has been directed at retarding the rate of age-related bone loss, and reducing the frequency and severity of trauma among elderly people, evidence is growing that peak bone mass is an important ...
Cooper, Cyrus, Harvey, Nicholas, Javaid, Kassim, Hanson, Mark, Dennison, Elaine   +4 more
openaire   +4 more sources

Impact of activating Notch signaling in osteocytes on osteogenic differentiation of bone marrow stromal cells in vitro

Di-san junyi daxue xuebao, 2020
Objective To investigate the effect and underlying mechanism of activating Notch signaling in osteocytes on osteogenic differentiation of bone marrow stromal cells (BMSCs). Methods The osteocytes derived from RosaNotch mice were infected with recombinant
XIE Yingchun, TU Xiaolin
doaj   +1 more source

Harnessing smart nanomaterials to reprogram neutrophil plasticity in immune modulation

Journal of Nanobiotechnology
Neutrophils are the most abundant type of white blood cells in the immune system and play a complex and intricate regulatory role in disease progression. Their critical contribution to maintaining homeostasis through migration, activation, and programmed
Jiaxin Luo, Jingxia Chen, Jing Zhou, Zhen Ci, Jian Feng, Xuyan Wei, Jingjie Zhai, Hanchi Wang, Yanmin Zhou   +8 more
doaj   +1 more source

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks, Molly Sonenklar, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler   +5 more
wiley   +1 more source

Ultra-Processed Food Impairs Bone Quality, Increases Marrow Adiposity and Alters Gut Microbiome in Mice

Foods, 2021
Ultra processed foods (UPF) consumption is becoming dominant in the global food system, to the point of being the most recent cause of malnutrition. Health outcomes of this diet include obesity and metabolic syndrome; however, its effect on skeletal ...
Tamara Travinsky-Shmul, Olga Beresh, Janna Zaretsky, Shelley Griess-Fishheimer, Reut Rozner, Rotem Kalev-Altman, Sveta Penn, Ron Shahar, Efrat Monsonego-Ornan   +8 more
doaj   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

The role of hypertrophic chondrocytes in fracture healing

生物医学转化, 2023
Fracture healing is a multifactorial process. Most fractures are healed by the process of endochondral ossification, involving the formation of a cartilaginous soft callus and the process of cartilage-tobone transition.
Zhu Daoyu, Gao Junjie, Gao Youshui
doaj   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

In Situ Valence Engineering of Copper Silicate Nanozymes with Enhanced Peroxidase‐Like Catalytic Activity for Oral Disease Detection

Advanced Science
As a series of attractive nanomaterials, nanozymes with great catalytic activity and specificity are well developed in the field of biosensors. Although promising, the lack of appropriate structural design strategy and limitation of sensing performance ...
Xiaocan Liu, Zhen Ding, Chengjing Xu, Jinming Zhang, Yufu Liu, Tianyan Chen, Shuang Dai, Xingfu Bao, Min Hu, Zhen Liu   +9 more
doaj   +1 more source