Results 11 to 20 of about 12,182,524 (404)

Paget's disease of bone [PDF]

open access: yesCalcified Tissue International, 1977
Paget’s disease of bone is a focal disorder of unknown etiology characterized initially by excessive resorption and subsequently by excessive formation of bone, culminating in a “mosaic” pattern of lamellar bone associated with extensive local vascularity and increased fibrous tissue in adjacent marrow.
Frederick R. Singer, Stephen M. Krane
openaire   +9 more sources

Autophagy and bone diseases

open access: yesJoint Bone Spine, 2022
Autophagy is a ubiquitous cellular process, allowing the removal and recycling of damaged proteins and organelles. At the basal level, this process plays a role in quality control, thus participating in cellular homeostasis. Autophagy can also be induced by various stresses, such as nutrient deprivation or hypoxia, to allow the cell to survive until ...
Trojani, Marie-Charlotte   +4 more
openaire   +6 more sources

Celiac disease and bone

open access: yesArchives of Endocrinology and Metabolism, 2022
Celiac disease (CD) is an autoimmune disorder characterized by small intestinal inflammation triggered by gluten ingestion in genetically-predisposed individuals. A frequent extra-intestinal manifestation of CD is metabolic bone disease which contributes to an increased risk of fracture.
Ananya V. Kondapalli   +1 more
openaire   +4 more sources

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]

open access: yes, 2014
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B   +6 more
core   +1 more source

Persistent vs Recurrent Cushing’s Disease Diagnosed Four Weeks Postpartum

open access: yesCase Reports in Endocrinology, 2022
Background. Cushing’s disease (CD) recurrence in pregnancy is thought to be associated with estradiol fluctuations during gestation. CD recurrence in the immediate postpartum period in a patient with a documented dormant disease during pregnancy has ...
Leena Shah   +3 more
doaj   +1 more source

Clinical characteristics of 10 Chinese patients with melorheostosis and identification of a somatic MAP2K1 variant in one case

open access: yesMolecular Genetics & Genomic Medicine, 2022
Background Melorheostosis (MEL) is an exceptionally rare sclerosing bone dysplasia with asymmetrically exuberant bone formation and soft tissue lesions in a segmental distribution.
Xiaojun Han   +5 more
doaj   +1 more source

Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis [PDF]

open access: yes, 2010
Introduction: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease ...
Bellantuono, I.   +8 more
core   +3 more sources

Mechanical behavior of osteoporotic bone at sub-lamellar length scales [PDF]

open access: yes, 2015
Osteoporosis is a disease known to promote bone fragility but the effect on the mechanical properties of bone material, which is independent of geometric effects, is particularly unclear.
Anna eShipov   +4 more
core   +2 more sources

Paget's disease of bone [PDF]

open access: yesThe Journal of Bone and Joint Surgery. British volume, 1979
This chapter focuses on Paget's disease of bone. The pathological hallmark of the Paget's bone disease is excessive and disorganized activity of bone that involves both matrix and mineral. There is no idea of its cause and little knowledge of its natural history; however, the biochemical changes produced by the overactive bone justify its inclusion as ...
openaire   +5 more sources

Clinicohematological and cytogenetic profile of myelodysplastic syndromes in Pakistan-compare and contrast

open access: yesMolecular Cytogenetics, 2017
Background Myelodysplastic syndromes (MDS) are clonal stem cell disorders exhibiting cytopenias, ineffective hematopoiesis and morphological dysplasia. Bone marrow cytogenetics, inspite of being incorporated as mandatory tool in diagnosis are done less ...
Nida Anwar   +7 more
doaj   +1 more source

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