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Bone changes in metabolic bone disease

Acta Orthopaedica Scandinavica, 1995
In order to secure the mechanical integrity of the skeleton bone undergoes constant renewal throughout life. This renewal process, bone remodeling, consists of the continuos removal of bone (bone resorption) followed by synthesis of new bone matrix and subsequent mineralization (bone formation).
E F, Eriksen, B, Langdahl
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Bone scintigraphy in metabolic bone disease

Seminars in Nuclear Medicine, 1997
The bone scan has well-recognized appearances in metabolic bone diseases, with its main clinical value found in focal conditions or the focal complications of disease. In clinical practice, the bone scan is most widely used to detect fractures in osteoporosis and pseudofractures in osteomalacia and to evaluate Paget's disease.
P J, Ryan, I, Fogelman
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Paget's disease of bone

Clinical Biochemistry, 2012
To review recent advance in understanding the causation and management of Paget's disease.We review recent publications concerning the aetiology of the disease and the use of biochemical markers of bone turnover in diagnosis and treatment.Epidemiologic studies suggest that Paget's disease is decreasing in prevalence and severity (implying that ...
Tim, Cundy, Ian R, Reid
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Paget's disease of bone

Calcified Tissue International, 1977
Paget’s disease of bone is a focal disorder of unknown etiology characterized initially by excessive resorption and subsequently by excessive formation of bone, culminating in a “mosaic” pattern of lamellar bone associated with extensive local vascularity and increased fibrous tissue in adjacent marrow.
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Myeloma and Bone Disease

Current Osteoporosis Reports, 2017
Bone disease is a defining characteristic of multiple myeloma (MM) and the major cause of morbidity. It manifests as lytic lesions or osteopenia and is often associated with severe pain, pathological fracture, spinal cord compression, vertebral collapse, and hypercalcemia.
Cristina, Panaroni   +2 more
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Caisson Disease of Bone

Clinical Orthopaedics and Related Research, 1986
Caisson disease of bone, which may affect compressed air workers and divers, is characterized by regions of bone and marrow necrosis that may lead to secondary osteoarthrosis of the hip and shoulder joints. A review of the pathologic, radiologic, and clinical aspects demonstrated uncertainties in the exact etiology.
P J, Gregg, D N, Walder
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Myeloma Bone Disease

Best Practice & Research Clinical Haematology, 2004
The major clinical manifestation of multiple myeloma is related to the osteolytic bone destruction. The bone disease can lead to pathologic fractures, spinal cord compression, hypercalcemia, and pain. It is also a major cause of morbidity and mortality in these patients.
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DISEASES OF BONE AND DISEASES AFFECTING BONE

Veterinary Surgery, 1975
SUMMARYDiseases of bones and diseases affecting bone are frequently related to breed, age, and limb involvement. The following checklist of diseases which may result in lameness are presented as a summation of the disease conditions likely to result in lameness in dog.
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Bone Marrow and Metabolic Bone Disease

Seminars in Musculoskeletal Radiology
AbstractThe bone marrow represents one of the largest organs in the body, with a relevant metabolic role that continues to be investigated. Numerous studies have focused on marrow adipose tissue (MAT). Evidence indicates that the bone marrow adipocytes do not only work as storage tissue but also consist of endocrine and paracrine cells, with the ...
Maria Pilar Aparisi Gómez   +1 more
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Bone Quality in Paget’s Disease of Bone

Current Osteoporosis Reports, 2016
Paget's disease of bone is produced by a localized increase in osteoclastic and osteoblastic activity which can progress slowly to involve an entire bone if untreated. A common feature is enlarged bones which are deformed, particularly in weight-bearing regions of the skeleton such as the lower extremity.
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