Results 91 to 100 of about 4,253,135 (331)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Determination of bone age based on hand radiography: from classical methods to artificial intelligence (a review)

Digital Diagnostics
Bone age assessment methods are crucial in diagnosing diseases associated with growth and developmental disorders, especially in pediatric practice.
Dmitry N. Reznikov, Dmitriy V. Kuligovskiy, Inna G. Vorontsova, Alexey V. Petraikin, Elena E. Petryaykina, Alexander E. Gordeev, Maria D. Varyukhina, Rustam A. Erizhokov, Olga V. Omelyanskaya, Anton V. Vladzymyrskyy   +9 more
doaj   +1 more source

Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring

International Journal of Molecular Sciences
Maternal obesity and over/undernutrition can have a long-lasting impact on offspring health during critical periods in the first 1000 days of life.
Benjamin N. Nelson, Jacob E. Friedman
semanticscholar   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Correlations between cancellous bone architecture and its dynamic behaviour [PDF]

, 2014
Previous studies showed that in vivo evaluation of the fracture risk of cancellous bone can be assessed by identifying the relationships between its microarchitecture description extracted from clinical imaging and its mechanical properties.
LAPORTE, Sébastien, SALETTI, Dominique, PATTOFATTO, Stéphane, BOUSSON, Valérie, PROT, Marianne   +4 more
core  

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis

Experimental and Molecular Medicine, 2023
Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties.
Li Liang, Fengmei Zhang, Naibo Feng, Biao Kuang, Mengtian Fan, Cheng Chen, Yiming Pan, Pengfei Zhou, Nana Geng, Xingyue Li, Menglin Xian, Lin Deng, Xiaoli Li, Liang Kuang, Fengtao Luo, Qiaoyan Tan, Yangli Xie, Fengjin Guo   +17 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A QTL for osteoporosis detected in an F2 population derived from White Leghorn chicken lines divergently selected for bone index [PDF]

, 2007
Osteoporosis, resulting from progressive loss of structural bone during the period of egg-laying in hens, is associated with an increased susceptibility to bone breakage.
Preisinger, R., Fleming, R H, Dunn, I. C., C. C. Whitehead, R. Preisinger, McCormack, H A, Morrice, D., Preisinger, R, Fleming, R. H., D. Morrice, R. H. Fleming, Burt, D. W., I. C. Dunn, Burt, D W, Dunn, I C, H. A. McCormack, McCormack, H. A., Whitehead, C. C., Morrice, D, Whitehead, C C, D. W. Burt   +20 more
core   +1 more source

Risk Factors for Low Bone Mineral Density in Institutionalized Individuals with Developmental Disabilities [PDF]

Health Promotion Perspectives, 2015
Background: Persons with intellectual/developmental disabilities (IDD) are exposed to several factors, which have been determined as risks for osteoporosis. Many of these individuals are non-ambulatory, resulting in lack of weight bearing activity, which
Michael A. Vice, Vinayak K. Nahar, M. Allison Ford, Martha A. Bass, Andrea K. Johnson, Ashton B. Davis, Rizwana Biviji-Sharma   +6 more
doaj   +1 more source

In situ licensing of mesenchymal stem cell immunomodulatory function via BMP-2 induced developmental process

Proceedings of the National Academy of Sciences of the United States of America
Significance Inflammatory factors, while enhancing the immunomodulatory capabilities of mesenchymal stem cells (MSCs), also upregulate the expression of cell surface histocompatibility antigens, compromising the immune privilege of MSCs. Here, we combine
Fu-Wei Zhu, Luli Ji, Kai Dai, Shunshu Deng, Jing Wang, Changsheng Liu   +5 more
semanticscholar   +1 more source