Results 101 to 110 of about 4,253,135 (331)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
HUMAN MESENCHYMAL STEM CELLS AS A MODEL OF STUDY FOR NEW BIOMATERIALS IN BONE TISSUE REGENERATION [PDF]
, 2012 The reconstruction of large bone segments remains a critical clinical problem in the case of extensive bone loss due to traumatic or pathological events. Due to its ideal biocompatibility and osteogenic properties, autologous bone is still considered the
Manfrini, Marco
core
Injectable Cell-based Tissue Engineered Bone Formulations [PDF]
, 2010 PhDCurrent golden standard therapy for bone repair and regeneration involves the use of auto grafts. Nevertheless, there are many drawbacks associated with auto grafts including donor site morbidity, requirement for an invasive surgery, post-operative
Ahmadi, Raheleh
core +4 more sources
Nutraceuticals and Functional Foods: A Comprehensive Review of Their Role in Bone Health
International Journal of Molecular SciencesBone health is the result of a tightly regulated balance between bone modeling and bone remodeling, and alterations of these processes have been observed in several diseases both in adult and pediatric populations.
M. Faienza +6 more
semanticscholar +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Stem cell migration - Methods and protocols
European Journal of Histochemistry, 2012 The trafficking of stem cells is something unconsciously clear to any biologists (e.g., developmental biologists) and physicians (e.g., all those taking care of hematopoietic and bone diseases and traumas); neverthless it is a phenomenon coming out as a ...
Carlo Alberto Redi
doaj +1 more source
Modeling of skeletal development and diseases using human pluripotent stem cells
Journal of Bone and Mineral ResearchHuman skeletal elements are formed from distinct origins at distinct positions of the embryo. For example, the neural crest produces the facial bones, the paraxial mesoderm produces the axial skeleton, and the lateral plate mesoderm produces the ...
H. Hojo, Shoichiro Tani, Shinsuke Ohba
semanticscholar +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Applied SciencesChronic kidney disease (CKD) is an extremely widespread pathology characterized by numerous metabolic alterations, including impairments of calcium–phosphorus and of vitamin D metabolisms, which lead to a condition known as CKD–mineral and bone disorders (CKD-MBDs).
Micaela Costacurta +4 more
openaire +4 more sources