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Type 2 diabetes affects bone cells precursors and bone turnover
BMC Endocrine Disorders, 2018 Background Here we study the effect of type 2 diabetes (T2DM) on bone cell precursors, turnover and cytokines involved in the control of bone cell formation and activity. Methods We enrolled in the study 21 T2DM women and 21 non diabetic controls matched
Francesca Sassi +12 more
doaj +1 more source
Development of Bone Targeting Drugs. [PDF]
, 2017 The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage
Alméciga-Díaz, Carlos J. +6 more
core +2 more sources
Frontiers in Physiology, 2020 Adipose tissue, as the largest endocrine organ, secretes many biologically active molecules circulating in the bloodstream, collectively termed adipocytokines, which not only regulate the metabolism but also play a role in pathophysiological processes ...
Bei Guo +12 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2021 Background Fragility fracture is associated with bone mineral density (BMD), and most databases used in related researches are instrument-matched.
Hong-Li Li +11 more
doaj +1 more source
Peri-implant diseases and metabolic syndrome components: a systematic review [PDF]
, 2018 OBJECTIVE: Metabolic syndrome (MetS) is defined as a spectrum of conditions associated with an increased risk of developing CVD and type 2 diabetes.
Letizia, C +6 more
core +1 more source
Genes and Diseases, 2023 Severe insulin resistance has been linked to some of the most globally prevalent disorders, such as diabetes mellitus, nonalcoholic fatty liver disease, polycystic ovarian syndrome, and hypertension. Hereditary severe insulin resistance syndrome (H-SIRS)
Junaid Iqbal +9 more
doaj +1 more source
Physiological conditions influencing regenerative potential of stem cells [PDF]
, 2016 Stem cells are being used in the treatment of cardivovascular diseases. Here, we review the physiologic and pathologic conditions that impact the regenerative potential of stem cells in the treatment of cardiovascular diseases which include the influence
Avitabile, Daniele +3 more
core +1 more source
Pharmacometrics and systems pharmacology for metabolic bone diseases.
British Journal of Clinical Pharmacology, 2019 Mathematical modelling and simulation (M&S) of drug concentrations, pharmacologic effects and the (patho)physiologic systems within which they interact can be powerful tools for the preclinical, translational and clinical development of drugs.
M. Riggs, S. Cremers
semanticscholar +1 more source
Frontiers in Endocrinology, 2022 Clinical vertebral fractures and femoral neck fractures are severe osteoporotic fractures that increase morbidity and mortality. Anthropometric variables are associated with an increased risk of osteoporotic fractures, but it is not clear whether body ...
Xi-Yu Wu +9 more
doaj +1 more source
Genetic approaches to metabolic bone diseases
British Journal of Clinical Pharmacology, 2018 Metabolic bone diseases comprise a diverse group of disorders characterized by alterations in skeletal homeostasis, and are often associated with abnormal circulating concentrations of calcium, phosphate or vitamin D metabolites.
F. Hannan +3 more
semanticscholar +1 more source