Zoledronic acid and atorvastatin inhibit αvβ3-mediated adhesion of breast cancer cells
Journal of Bone Oncology, 2014 Bone metastases represent common long term complications of patients with breast cancer. Zoledronic acid, an amino-bisphosphonate and mevalonate pathway inhibitor, is an established agent for the treatment of bone metastases.
Maria Wilke +8 more
doaj +1 more source
High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes [PDF]
, 2018 Purpose: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation.
Carnevale, V. +9 more
core +1 more source
Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism [PDF]
, 2018 C.L.-O. is supported by grants from the European Union (ERC-2016-ADG, DeAge); Ministerio de Economía y Competitividad (MINECO/FEDER: SAF2014-52413-R and SAF2017-87655-R); Instituto de Salud Carlos III (RTICC); Progeria Research Foundation (PRF2016-66 ...
Bárcena Fernández, Clea +11 more
core +3 more sources
Non-neural phenotype of spinal and bulbar muscular atrophy: Results from a large cohort of Italian patients [PDF]
, 2016 Objective: To carry out a deep characterisation of the main androgen-responsive tissues involved in spinal and bulbar muscular atrophy (SBMA). Methods: 73 consecutive Italian patients underwent a full clinical protocol including biochemical and hormonal ...
Angelini, Lorenzo +37 more
core +1 more source
Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease
International Journal of Endocrinology, 2020 Exosomes are a type of extracellular vehicle, formed by budding cell membranes, containing proteins, DNA, and RNA. Concentrated cargoes from parent cells are enveloped in exosomes, which are cell specific and may have functions in the recipient cell ...
Yi Wang +7 more
doaj +1 more source
Exosomes and Obesity-Related Insulin Resistance
Frontiers in Cell and Developmental Biology, 2021 Exosomes are extracellular vesicles, delivering signal molecules from donor cells to recipient cells. The cargo of exosomes, including proteins, DNA and RNA, can target the recipient tissues and organs, which have an important role in disease development.
Li-Min Lei +9 more
doaj +1 more source
A novel model to explain dietary factors affecting hypocalcaemia in dairy cattle [PDF]
, 2011 Most dairy cows exhibit different degrees of hypocalcaemia around calving because the gestational Ca requirements shift to the disproportionately high Ca requirements of lactation.
Martin-Tereso Lopez, J. +1 more
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Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice [PDF]
, 2017 © 2017 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd. INTRODUCTION: Fatty liver disease is prevalent in populations with high caloric intake.
Asai +50 more
core +1 more source
Short- and long-term effects of a multi-component physical activity intervention in primary school [PDF]
, 2012 There is compelling evidence that physical activity has numerous health benefits during childhood and adolescence. Insufficient levels of physical activity on the other hand can consequently affect cardiovascular and bone health, which may result in ...
Meyer, Ursina
core +1 more source
A novel antimicrobial peptide derived from human BPIFA1 protein protects against infection
Innate Immunity, 2022 Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is an innate immunity defense protein. Our previous studies proved its antibacterial and antiviral effects, but its role in fungi remains unknown.
Nan Hu +6 more
doaj +1 more source