Results 21 to 30 of about 910,494 (304)
Genes and Diseases, 2023 Severe insulin resistance has been linked to some of the most globally prevalent disorders, such as diabetes mellitus, nonalcoholic fatty liver disease, polycystic ovarian syndrome, and hypertension. Hereditary severe insulin resistance syndrome (H-SIRS)
Junaid Iqbal +9 more
doaj +1 more source
International Journal of Molecular Sciences, 2021 In a healthy body, homeostatic actions of osteoclasts and osteoblasts maintain the integrity of the skeletal system. When cellular activities of osteoclasts and osteoblasts become abnormal, pathological bone conditions, such as osteoporosis, can occur ...
P.S.U. Park +5 more
semanticscholar +1 more source
Ferroptosis and Its Potential Role in Metabolic Diseases: A Curse or Revitalization?
Frontiers in Cell and Developmental Biology, 2021 Ferroptosis is classified as an iron-dependent form of regulated cell death (RCD) attributed to the accumulation of lipid hydroperoxides and redox imbalance.
Jia-Yue Duan +13 more
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Reactive Oxygen Species (ROS)-Responsive Biomaterials for the Treatment of Bone-Related Diseases
Frontiers in Bioengineering and Biotechnology, 2022 Reactive oxygen species (ROS) are the key signaling molecules in many physiological signs of progress and are associated with almost all diseases, such as atherosclerosis, aging, and cancer.
Xiaoxiang Ren +5 more
semanticscholar +1 more source
Pharmacometrics and systems pharmacology for metabolic bone diseases.
British Journal of Clinical Pharmacology, 2019 Mathematical modelling and simulation (M&S) of drug concentrations, pharmacologic effects and the (patho)physiologic systems within which they interact can be powerful tools for the preclinical, translational and clinical development of drugs.
M. Riggs, S. Cremers
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Frontiers in Endocrinology, 2022 Clinical vertebral fractures and femoral neck fractures are severe osteoporotic fractures that increase morbidity and mortality. Anthropometric variables are associated with an increased risk of osteoporotic fractures, but it is not clear whether body ...
Xi-Yu Wu +9 more
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Genetic approaches to metabolic bone diseases
British Journal of Clinical Pharmacology, 2018 Metabolic bone diseases comprise a diverse group of disorders characterized by alterations in skeletal homeostasis, and are often associated with abnormal circulating concentrations of calcium, phosphate or vitamin D metabolites.
F. Hannan +3 more
semanticscholar +1 more source
British Journal of Clinical Pharmacology, 2018 Regulation of medicines involves complex scientific and public health policies which are reflected in the regulatory approaches used by the European Medicines Agency and the United States Food and Drug Administration for the approval of products ...
T. Kehoe, E. Blind, Heidi Janssen
semanticscholar +1 more source
Zoledronic acid and atorvastatin inhibit αvβ3-mediated adhesion of breast cancer cells
Journal of Bone Oncology, 2014 Bone metastases represent common long term complications of patients with breast cancer. Zoledronic acid, an amino-bisphosphonate and mevalonate pathway inhibitor, is an established agent for the treatment of bone metastases.
Maria Wilke +8 more
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Gaucher disease: the role of the specialist on metabolic bone diseases.
CLINICAL CASES IN MINERAL AND BONE METABOLISM, 2015 According to European legislation, a disease can be considered rare or "orphan" when it affects less than 1 subject of 2000 (1). Often these diseases affecting the pediatric age, are complex diseases and chronically debilitating and for this motive need ...
L. Masi, M. Brandi
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