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Calcified Tissue International, 2019
Paget's disease of bone (PDB) is a chronic and focal bone disorder, characterized by increased osteoclast-mediated bone resorption and a subsequent compensatory increase in bone formation, resulting in a disorganized mosaic of woven and lamellar bone at one or more affected skeletal sites.
Luigi Gennari +3 more
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Paget's disease of bone (PDB) is a chronic and focal bone disorder, characterized by increased osteoclast-mediated bone resorption and a subsequent compensatory increase in bone formation, resulting in a disorganized mosaic of woven and lamellar bone at one or more affected skeletal sites.
Luigi Gennari +3 more
openaire +5 more sources
Endocrinology and Metabolism Clinics of North America, 2015
Pituitary hormones have direct and indirect effects on bone remodeling, and skeletal fragility is a frequent complication of pituitary diseases. Fragility fractures may occur in many patients with prolactinomas, acromegaly, Cushing disease, and hypopituitarism.
MAZZIOTTI, Gherardo +2 more
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Pituitary hormones have direct and indirect effects on bone remodeling, and skeletal fragility is a frequent complication of pituitary diseases. Fragility fractures may occur in many patients with prolactinomas, acromegaly, Cushing disease, and hypopituitarism.
MAZZIOTTI, Gherardo +2 more
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Bone changes in metabolic bone disease
Acta Orthopaedica Scandinavica, 1995In order to secure the mechanical integrity of the skeleton bone undergoes constant renewal throughout life. This renewal process, bone remodeling, consists of the continuos removal of bone (bone resorption) followed by synthesis of new bone matrix and subsequent mineralization (bone formation).
E F, Eriksen, B, Langdahl
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Bone scintigraphy in metabolic bone disease
Seminars in Nuclear Medicine, 1997The bone scan has well-recognized appearances in metabolic bone diseases, with its main clinical value found in focal conditions or the focal complications of disease. In clinical practice, the bone scan is most widely used to detect fractures in osteoporosis and pseudofractures in osteomalacia and to evaluate Paget's disease.
P J, Ryan, I, Fogelman
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Clinical Biochemistry, 2012
To review recent advance in understanding the causation and management of Paget's disease.We review recent publications concerning the aetiology of the disease and the use of biochemical markers of bone turnover in diagnosis and treatment.Epidemiologic studies suggest that Paget's disease is decreasing in prevalence and severity (implying that ...
Tim, Cundy, Ian R, Reid
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To review recent advance in understanding the causation and management of Paget's disease.We review recent publications concerning the aetiology of the disease and the use of biochemical markers of bone turnover in diagnosis and treatment.Epidemiologic studies suggest that Paget's disease is decreasing in prevalence and severity (implying that ...
Tim, Cundy, Ian R, Reid
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Clinical Orthopaedics and Related Research, 1986
Caisson disease of bone, which may affect compressed air workers and divers, is characterized by regions of bone and marrow necrosis that may lead to secondary osteoarthrosis of the hip and shoulder joints. A review of the pathologic, radiologic, and clinical aspects demonstrated uncertainties in the exact etiology.
P J, Gregg, D N, Walder
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Caisson disease of bone, which may affect compressed air workers and divers, is characterized by regions of bone and marrow necrosis that may lead to secondary osteoarthrosis of the hip and shoulder joints. A review of the pathologic, radiologic, and clinical aspects demonstrated uncertainties in the exact etiology.
P J, Gregg, D N, Walder
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Best Practice & Research Clinical Haematology, 2004
The major clinical manifestation of multiple myeloma is related to the osteolytic bone destruction. The bone disease can lead to pathologic fractures, spinal cord compression, hypercalcemia, and pain. It is also a major cause of morbidity and mortality in these patients.
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The major clinical manifestation of multiple myeloma is related to the osteolytic bone destruction. The bone disease can lead to pathologic fractures, spinal cord compression, hypercalcemia, and pain. It is also a major cause of morbidity and mortality in these patients.
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Calcified Tissue International, 1977
Paget’s disease of bone is a focal disorder of unknown etiology characterized initially by excessive resorption and subsequently by excessive formation of bone, culminating in a “mosaic” pattern of lamellar bone associated with extensive local vascularity and increased fibrous tissue in adjacent marrow.
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Paget’s disease of bone is a focal disorder of unknown etiology characterized initially by excessive resorption and subsequently by excessive formation of bone, culminating in a “mosaic” pattern of lamellar bone associated with extensive local vascularity and increased fibrous tissue in adjacent marrow.
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DISEASES OF BONE AND DISEASES AFFECTING BONE
Veterinary Surgery, 1975SUMMARYDiseases of bones and diseases affecting bone are frequently related to breed, age, and limb involvement. The following checklist of diseases which may result in lameness are presented as a summation of the disease conditions likely to result in lameness in dog.
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Bone Quality in Paget’s Disease of Bone
Current Osteoporosis Reports, 2016Paget's disease of bone is produced by a localized increase in osteoclastic and osteoblastic activity which can progress slowly to involve an entire bone if untreated. A common feature is enlarged bones which are deformed, particularly in weight-bearing regions of the skeleton such as the lower extremity.
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