Results 61 to 70 of about 3,945,300 (210)

Muscle and bone characteristics of a Chinese family with spinal muscular atrophy, lower extremity predominant 1 (SMALED1) caused by a novel missense DYNC1H1 mutation

BMC Medical Genomics, 2023
Background Spinal muscular atrophy, lower extremity predominant (SMALED) is a type of non-5q spinal muscular atrophy characterised by weakness and atrophy of lower limb muscles without sensory abnormalities.
Yazhao Mei, Yunyi Jiang, Zhenlin Zhang, Hao Zhang   +3 more
doaj   +1 more source

Th17 and Treg Cells in Bone Related Diseases [PDF]

, 2013
Bone-related diseases share the process of immune response that targets bone tissue and bone marrow and then induce adverse effects on structure and function.
Shuang Yu, Min Wang, Daoxin Ma, Tian Tian, Na He   +4 more
core   +1 more source

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

Scientific Reports, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V. Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviele   +9 more
doaj   +1 more source

Myeloma bone disease

Hematology, 2005
Bone destruction is a hallmark of multiple myeloma, and recent studies demonstrated a strong interdependence between tumor progression and bone resorption. Increased bone resorption as a major characteristic of multiple myeloma is caused by osteoclast activation and osteoblast inhibition (uncoupling).
openaire   +2 more sources

Cancer-associated bone disease [PDF]

, 2013
Bone is commonly affected in cancer. Cancer-induced bone disease results from the primary disease, or from therapies against the primary condition, causing bone fragility.
Chappard, Daniel, Kendler, D, El Hajj Fuleihan, G., Cannata-Andia, J., T.J. de Villiers, Glüer, C. C., Napoli, Nicola, A. Papaioannou, J. Cannata-Andia, Pierroz, Dominique, D. Chappard, Pierroz, D.D., M. Rahme, G. Fuleihan El Hajj, Rizzoli, René, Fuleihan El Hajj, G., El Maghraoui, Abdellah, Papaioannou, Alexandra, R. Rizzoli, A. El Maghraoui, Brandi, M.-L., Papaioannou, A, Hajj Fuleihan, G., Rahme, M., Cannata-Andía, Jorge J.B., C.C. Glüer, N. Napoli, Van Poznak, C. H., J.J. Body, Cannata Andía, Jorge Benito, Body, J.-J., Chappard, D., Body, J-J, El Hajj Fuleihan, Ghada, Van Poznak, Catherine Van, Brandi, M.L., Poznak, C. H., de Villiers, T, Rizzoli, R., D. Kendler, Papaioannou, A., Glüer, C.-C., Brandi, M. -L., D.D. Pierroz, Glüer, C.C., Rahme, Maya, C.H. Van Poznak, van Poznak, C.H., Pierroz, D. D., Villiers, T. J. de, M.L. Brandi, Rizzoli, R, Kendler, David, Body, J. J., El Maghraoui, A., Villiers, T. J., Kendler, D., Rahme, M, Cannata-Andia, J, Pierroz, D., Napoli, N., De Villiers, Tobie, Maghraoui, A., Body, Jean-Jacques, El Hajj Fuleihan G., Chappard D., El Maghraoui A, Chappard D, Papaioannou A, Rizzoli R., Rahme M, Brandi ML, Pierroz DD, De Villiers T.J., Cannata-Andia J., Rizzoli R, de Villiers TJ, Napoli N., Glüer CC, Body JJ, Body J.-J., Rahme M., Van Poznak C.H., Napoli N, Gluer C.C., Brandi M.-L., Kendler D., Papaioannou A., El Hajj Fuleihan G, Van Poznak CH, Pierroz D.D., El Maghraoui A., Cannata-Andia J, Kendler D   +93 more
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Neuromuscular Diseases and Bone

Frontiers in Endocrinology, 2019
Neuromuscular diseases (NMDs) are inherited or acquired conditions affecting skeletal muscles, motor nerves, or neuromuscular junctions. Most of them are characterized by a progressive damage of muscle fibers with reduced muscle strength, disability, and poor health-related quality of life of affected patients.
Iolascon G, Paoletta M, Liguori S, Curci C, MORETTI A   +4 more
openaire   +4 more sources

Type 2 diabetes affects bone cells precursors and bone turnover

BMC Endocrine Disorders, 2018
Background Here we study the effect of type 2 diabetes (T2DM) on bone cell precursors, turnover and cytokines involved in the control of bone cell formation and activity. Methods We enrolled in the study 21 T2DM women and 21 non diabetic controls matched
Francesca Sassi, Ilaria Buondonno, Chiara Luppi, Elena Spertino, Emanuela Stratta, Marco Di Stefano, Marco Ravazzoli, Gianluca Isaia, Marina Trento, Pietro Passera, Massimo Porta, Giovanni Carlo Isaia, Patrizia D’Amelio   +12 more
doaj   +1 more source

IGF-I signalling in bone growth: Inhibitory actions of dexamethasone and IL-1 beta [PDF]

, 2007
To determine if glucocorticoids and proinflammatory cytokines inhibit bone growth through a common mechanism involving impaired IGF-I ...
Macrae, V.E., Ahmed, S Faisal, Ahmed, S.F., Mushtaq, Talat, Farquharson, C., Farquharson, Colin; id_orcid, Macrae, Vicky E, Mushtaq, T.   +7 more
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Role of senescent cells in bone-related diseases: An updated review [PDF]

Bone-related diseases are a group of inflammatory diseases characterized by abnormal bone resorption and formation, with a wide variety of diseases involving age, inflammation, obesity, genetics, radiation, and other pathogenic factors.
TANG Jinru, LI Bo, LIU Yunkun, HOU Zeyu, LI Longjiang
core   +1 more source

Quantitative Ultrasound of Cortical Bone in the Femoral Neck Predicts Femur Strength: Results of a Pilot Study [PDF]

, 2013
Article first published online: 15 JAN 2013 Pour consulter la version éditeur DOI: 10.1002/jbmr.1742A significant risk of femoral neck (FN) fracture exists for men and women with an areal bone mineral density (aBMD) higher than the osteoporotic range ...
GRONDIN, Julien, ENGELKE, Klaus, Reinhard Barkmann, GRIMAL, Quentin, Quentin Grimal, Sandra Guérard, Glüer, Claus-C., Julien Grondin, GUÉRARD, Sandra, Klaus Engelke, GLÜER, Claus-C, BARKMANN, Reinhard, Claus‐C Glüer, Pascal Laugier, LAUGIER, Pascal   +14 more
core   +1 more source