Results 251 to 260 of about 2,383,550 (356)

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Beyond Bone Grafts: Exploring the Efficacy of Alternative Regenerative Therapies. [PDF]

Cureus
Gerova-Vatsova T.
europepmc   +1 more source

Intestinal and multiple organ transplantation [PDF]

, 2000
Abu-Elmagd, K, Bueno, J, Mazariegos, G, Reyes, J, Selby, R, Starzl, TE, Todo, S   +6 more
core  

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Three-Dimensional-Printed Bone Grafts for Simultaneous Bone and Cartilage Regeneration: A Promising Approach to Osteochondral Tissue Engineering. [PDF]

Pharmaceutics
Paraš S, Petrović B, Mitić D, Lazarević M, Popović Bajić M, Živković M, Mićić M, Biočanin V, Živković S, Jokanović V.   +9 more
europepmc   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Evaluation of the results of reconstruction of large bony defects of humerus using vascularized bone grafts. [PDF]

J Hand Microsurg
Youssef M, AbdalMoneim Hafez M, Elsayed Semaya A, El-Sayed A.   +3 more
europepmc   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Long-Term Bone Height Changes After Sinus Floor Elevation With Maxillary or Mandibular Bone Grafts: A Radiological Study. [PDF]

Clin Implant Dent Relat Res
Bouwman WF, Eijsackers FA, Bravenboer N, Ten Bruggenkate CM, Remmelzwaal S, Schulten EAJM.   +5 more
europepmc   +1 more source

Plerixafor alone for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells [PDF]

, 2019
Chen, Yi-Bin, DiPersio, John F., et al,
core   +1 more source