Results 261 to 270 of about 2,383,550 (356)

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

It is not waste if it is therapy: cellular, secretory and functional properties of reamer-irrigator-aspirator (RIA)-derived autologous bone grafts. [PDF]

J Orthop Traumatol
Häusner S, Kolb A, Übelmesser K, Hölscher-Doht S, Jordan MC, Jauković A, Berberich-Siebelt F, Spasovski DV, Groll J, Blunk T, Herrmann M.   +10 more
europepmc   +1 more source

Inzidenz der Pankreasfistel nach segmentaler Pankreastransplantation [PDF]

, 1986
Abendroth, D., Gottwald, T., Illner, Wolf-Dieter, Land, W.   +3 more
core  

Biodegradable Adhesive Systems for Bio‐Integrated Applications

Advanced Science, EarlyView.
Biodegradable adhesives provide temporary yet reliable adhesion while degrading into safe, non‐toxic by‐products under physiological or environmental conditions. This review summarizes recent developments in physical and chemical adhesion mechanisms—including hydrogen bonding, catechol chemistry, amine‐carboxyl coupling, and emerging diazirine and urea
Won Bae Han, Sungkeun Han, Prashant Shivaji Shewale, Hyewon Cho, Li‐Hyun Kim, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +6 more
wiley   +1 more source

Bioabsorbable Endovascular Adhesive Tape (BEAT) for Improving Vascular Regeneration

Advanced Science, EarlyView.
A bioabsorbable endovascular adhesive tape (BEAT) platform based on a hierarchical polyelectrolyte complex is developed to enhance drug delivery in the DCB system. The coating enables rapid transfer to the vessel, provides short‐term mechanical support, and promotes both immediate transfer and long‐term retention of drugs at the lesion site.
Jiarong Wang, Jing Wang, Xinyi Li, Bo Yu, Yiduo Chen, Yirong Guo, Honglin Qian, Meng Hu, Haoyang Liu, Wenhui Liu, Han Xu, Kefeng Ren, M. Cristina L. Martins, Jian Ji   +13 more
wiley   +1 more source

Clavicle Shaft Non-Unions-Do We Even Need Bone Grafts? [PDF]

J Clin Med
Mühlenfeld N, Wagner FC, Hupperich A, Heykendorf L, Frodl A, Obid P, Kühle J, Schmal H, Erdle B, Jaeger M.   +9 more
europepmc   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Comparing Lumbar Spine Cages and Bone Grafts in Spinal Arthrodesis: A Meta-Analysis of Clinical Outcomes. [PDF]

Cureus
Almohammadi Y, Albduljabbar A, Almosa A, Alalwani Y, Abdulshakur A, Alzuwayhiri R, Alenezi A, Azzam AY.   +7 more
europepmc   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Comparative Evaluation of Mathematical Model and In Vivo Study of Calcium Phosphate Bone Grafts. [PDF]

J Funct Biomater
Shlykov MA, Smirnova PV, Senotov AS, Teterina AY, Minaychev VV, Smirnov IV, Novikov RA, Marchenko EI, Salynkin PS, Komlev VS, Fadeev RS, Fadeeva IS.   +11 more
europepmc   +1 more source