Results 61 to 70 of about 501,666 (360)

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Fracture Healing Is Delayed in Immunodeficient NOD/scid‑IL2Rγcnull Mice. [PDF]

PLoS ONE, 2016
Following bone fracture, the repair process starts with an inflammatory reaction at the fracture site. Fracture healing is disturbed when the initial inflammation is increased or prolonged, whereby, a balanced inflammatory response is anticipated to be ...
Anna E Rapp, Ronny Bindl, Stefan Recknagel, Annika Erbacher, Ingo Müller, Hubert Schrezenmeier, Christian Ehrnthaller, Florian Gebhard, Anita Ignatius   +8 more
doaj   +1 more source

Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists [PDF]

, 2017
Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of fracture, poor bone healing and other skeletal complications.
Chantal Chenu, Guillaume Mabilleau, Iepsen, Iepsen, Marie Pereira   +4 more
core   +4 more sources

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Bone morphogenetic proteins − 7 and − 2 in the treatment of delayed osseous union secondary to bacterial osteitis in a rat model [PDF]

, 2018
Background: Bone infections due to trauma and subsequent delayed or impaired fracture healing represent a great challenge in orthopedics and trauma surgery.
A Moghaddam, A Moghaddam-Alvandi, Adriana Ivanova, AH Nguyen, AL Jones, AP Hughes, B Wildemann, Britt Wildemann, C Papakostidis, CA Tannoury, CP Miller, DJ Hak, E Vogelin, G Bode, G Schmidmaier, G Schmidmaier, G Walter, Georg W. Omlor, Gerhard Schmidmaier, J Josse, J. Philippe Kretzer, JA Wright, JM Lane, KV Brown, L Helbig, L Shi, Lars Helbig, LC Gerstenfeld, M Fassbender, M Lucke, M Lucke, MB Nair, MF Swiontkowski, N Otsu, P Bosemark, P Garcia, P Schwabe, PS Brannan, PV Giannoudis, PV Giannoudis, R Marsell, Robert Sonntag, S Govender, SA Guelcher, SD Cook, Susann Minkwitz, Thorsten Guehring, V Chadayammuri, X Chen, X Chen, YH An   +50 more
core   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Mechanisms and new advances in the efficacy of plant active ingredients in tendon-bone healing

Journal of Orthopaedic Surgery and Research
The tendon-bone interface, known as the tenosynovial union or attachment, can be easily damaged by excessive exercise or trauma. Tendon-bone healing is a significant research topic in orthopedics, encompassing various aspects of sports injuries and ...
Yuan Li, Wei Wang, Wensheng Xu
doaj   +1 more source

Modulation of the Inflammatory Response and Bone Healing

Frontiers in Endocrinology, 2020
The optimal treatment for complex fractures and large bone defects is an important unsolved issue in orthopedics and related specialties. Approximately 5–10% of fractures fail to heal and develop non-unions.
Masahiro Maruyama, Claire Rhee, Takeshi Utsunomiya, Ning Zhang, Masaya Ueno, Zhenyu Yao, Stuart B. Goodman, Stuart B. Goodman   +7 more
doaj   +1 more source

Single-Cell RNA Sequencing Reveals B Cells Are Important Regulators in Fracture Healing

Frontiers in Endocrinology, 2021
The bone marrow microenvironment is composed primarily of immune and stromal cells that play important roles in fracture healing. Although immune cells have been identified in mouse bone marrow, variations in their numbers and type during the fracture ...
Hao Zhang, Renkai Wang, Renkai Wang, Guangchao Wang, Bo Zhang, Chao Wang, Di Li, Chen Ding, Qiang Wei, Zhenyu Fan, Hao Tang, Fang Ji, Fang Ji   +12 more
doaj   +1 more source

Comparison of osseointegration in piezoimplants versus cylindrical implants [PDF]

, 2019
BACKGROUND: Dental implants have been successful for the restoration of edentulous areas, but current techniques are inadequate in areas lacking sufficient bone volume. Piezoelectric surgery has shown encouraging effects on both osseous healing.
Fujinaka, Trevor
core