Results 71 to 80 of about 281,009 (311)

Graft healing in anterior cruciate ligament reconstruction

Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology, 2009
Successful anterior cruciate ligament reconstruction with a tendon graft necessitates solid healing of the tendon graft in the bone tunnel. Improvement of graft healing to bone is crucial for facilitating an early and aggressive rehabilitation and ...
Chen Chih-Hwa
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Strontium ranelate stimulates trabecular bone formation in a rat tibial bone defect healing process [PDF]

, 2017
Strontium ranelate treatment is known to prevent fractures. Here, we showed that strontium ranelate treatment enhances bone healing and affects bone cellular activities differently in intact and healing bone compartments: Bone formation was increased ...
Chappard, Daniel, R. Rizzoli, Rizzoli, R, G. Mabilleau, Lavet, Cedric, Ammann, Patrick, Lavet, C, D. Chappard, Mabilleau, Guillaume, Mabilleau, G., P. Ammann, Chappard, D., Rizzoli, René, C. Lavet   +13 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Manipulating fibrin structure of hematomas enhances large bone defects healing

, 2016
Hematomas (blood clots) are known important factors in early stages of fracture repair. This project characterized the differences in hematomas between normal healing and delayed healing in bone defects.
Wang, Xin
core   +1 more source

The role of bone sialoprotein in bone healing

Journal of Structural Biology
Bone sialoprotein (BSP) is a multi-functional extracellular matrix (ECM) protein associated with mineralized tissues, particularly bone and cementum. The amino acid sequence of BSP includes three evolutionarily conserved sequences which contribute to functions of the protein: an N-terminal collagen-binding domain, polyglutamic acid (polyE) sequences ...
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Formation of blood clot on biomaterial implants influences bone healing

, 2014
The first step in bone healing is forming a blood clot at injured bones. During bone implantation, biomaterials unavoidably come into direct contact with blood, leading to a blood clot formation on its surface prior to bone regeneration.
Ben Goss, Cameron Lutton, Shiu, Hoi Ting, Hoi Ting Shiu, Cameron, Lutton, Crawford, Ross, Xiao, Yin, Yin Xiao, Goss, Ben, Ross Crawford   +9 more
core   +1 more source

Potential Effects of Myrmecodia Pendants (Ant Nests) on Healing Bone Injuries

Biology, Medicine & Natural Product Chemistry
Myrmecodia pendens is a medical plant that can have a healing effect on bone injuries. Bone injuries can occur due to many things, including injuries due to infection, non-infection, degeneration and neoplasms.
Adilla Syahsiyatun Najah, Akram La Kilo, Ahmad Kadir   +2 more
doaj   +1 more source

Biological fixation in anterior cruciate ligament surgery

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 2014
Successful anterior cruciate ligament (ACL) reconstruction with tendon graft requires extensive tendon-to-bone healing in the bone tunnels and progressive graft ligamentization for biological, structural, and functional recovery of the ACL.
Chih-Hwa Chen, Chian-Her Lee
doaj   +1 more source