Results 81 to 90 of about 281,009 (311)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Influence of the mechanical environment upon the healing of segmental bone defects in the rat femur [PDF]
Loss of large segments of bone creates critical size defects (CSDs). These fail to heal spontaneously and present major clinical challenges to orthopaedic surgeons. The research described in this thesis is based upon the hypothesis that the healing of
Glatt, Vaida
core
BONE HEALING IN MICE: DOES IT FOLLOW GENERIC MECHANO-REGULATION RULES?
Facta Universitatis. Series: Mechanical Engineering, 2015 Mechanical signals are known to influence bone healing progression. Previous studies have postulated inter-species differences in the mechanical regulation of the bone healing process.
Edoardo Borgiani +3 more
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The Effect of Oral Isotretinoin on Bone Healing in Rabbit Rhinoplasty Model: An Experimental Study
İstanbul Medical Journal, 2019 Introduction:Since the age at which rhinoplasty is frequently performed is also the age at which acne is frequently seen, a person may be a candidate for both this surgery and isotretinoin therapy.
Şahin Öğreden +2 more
doaj +1 more source
Bone physiology and bone healing [PDF]
Neurosurgical Focus, 2002 In the not-too-distant past, spine surgeons performed spinal arthrodesis procedures and bone union would occur. This wish, however, was often not realized, and a nonunion (pseudarthrosis) developed in 10 to 45% of patients. Although the introduction of adjunctive spinal instrumentation reduced the nonunion rate, it remained significant, ranging from 5 ...
openaire +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Effect of nicotine on bone healing in rats - A histological study [PDF]
Al Ameen Journal of Medical Sciences, 2014 Background & Objectives: Nicotine is the major alkaloid in tobacco products (Nicotiona tabacum) and a psychoactive ingredient responsible for the Central Nervous System (CNS) effects and tobacco addiction.
Dilip Kumar Rayapati +6 more
doaj
International Journal of Dentistry, 2014 This study aimed at investigating if a coating of hydroxyapatite nanocrystals would enhance bone healing over time in trabecular bone. Sandblasted and acid etched titanium implants with and without a submicron thick coat of hydroxyapatite nanocrystals ...
Lory Melin Svanborg +6 more
doaj +1 more source