Results 21 to 30 of about 906,794 (309)

Assessing disease experience across the life span for individuals with osteogenesis imperfecta: challenges and opportunities for patient-reported outcomes (PROs) measurement: a pilot study

Orphanet Journal of Rare Diseases, 2019
Background Patient reported outcome (PRO) information is crucial for establishing better patient-provider communication, improving shared decision-making between clinicians and patients, assessing patient responses to therapeutic interventions, and ...
Laura L. Tosi, Marianne K. Floor, Christina M. Dollar, Austin P. Gillies, Members of the Brittle Bone Disease Consortium, Tracy S. Hart, David D. Cuthbertson, V. Reid Sutton, Jeffrey P. Krischer   +8 more
doaj   +1 more source

Micro-CT Analysis of Spine Architecture in a Mouse Model of Scoliosis

Frontiers in Endocrinology, 2015
Objective: Mice homozygous for targeted deletion of the gene encoding fibroblast growth factor receptor 3 (FGFR3-/-) develop kyphoscoliosis by two months of age.
Chan eGao, Chan eGao, Brian P Chen, Brian P Chen, Michael B Sullivan, Michael B Sullivan, Jasmine eHui, Jasmine eHui, Jean eOuellet, Janet E Henderson, Janet E Henderson, Janet E Henderson, Neil eSaran   +12 more
doaj   +1 more source

Bone Health

EDIS, 2012
“When planning your family meals, you probably try to make sure your children get enough calcium and vitamin D, perhaps including a fresh cup of milk. Since milk is full of calcium, vitamin D, and other important nutrients, it’s one of the best foods for building strong bones.
Jacob Young, Jennifer Hillan
openaire   +5 more sources

p21−/− mice exhibit enhanced bone regeneration after injury

BMC Musculoskeletal Disorders, 2017
Background p21(WAF1/CIP1/SDI1), a cyclin dependent kinase inhibitor has been shown to influence cell proliferation, differentiation and apoptosis; but more recently, p21 has been implicated in tissue repair.
Priyatha Premnath, Britta Jorgenson, Ricarda Hess, Pankaj Tailor, Dante Louie, Jaymi Taiani, Steven Boyd, Roman Krawetz   +7 more
doaj   +1 more source

Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide

BMC Cell Biology, 2017
Background Self-renewal and differentiation of embryonic stem cells (ESCs) is directed by biological and/or physical cues that regulate multiple signaling cascades. We have previously shown that mESCs seeded in a type I collagen matrix demonstrate a loss
Olesja Hazenbiller, Neil A. Duncan, Roman J. Krawetz   +2 more
doaj   +1 more source

Comprehensive network modeling from single cell RNA sequencing of human and mouse reveals well conserved transcription regulation of hematopoiesis

BMC Genomics, 2020
Background Presently, there is no comprehensive analysis of the transcription regulation network in hematopoiesis. Comparison of networks arising from gene co-expression across species can facilitate an understanding of the conservation of functional ...
Shouguo Gao, Zhijie Wu, Xingmin Feng, Sachiko Kajigaya, Xujing Wang, Neal S. Young   +5 more
doaj   +1 more source

Understanding cartilage protection in OA and injury: a spectrum of possibilities

BMC Musculoskeletal Disorders, 2020
Background Osteoarthritis (OA) is a prevalent musculoskeletal disease resulting in progressive degeneration of the hyaline articular cartilage within synovial joints.
Anand O. Masson, Roman J. Krawetz
doaj   +1 more source

Automatic segmentation of trabecular and cortical compartments in HR-pQCT images using an embedding-predicting U-Net and morphological post-processing

Scientific Reports, 2023
High-resolution peripheral quantitative computed tomography (HR-pQCT) is an emerging in vivo imaging modality for quantification of bone microarchitecture.
Nathan J. Neeteson, Bryce A. Besler, Danielle E. Whittier, Steven K. Boyd   +3 more
doaj   +1 more source

Predicting Angiogenesis by Endothelial Progenitor Cells Relying on In-Vitro Function Assays and VEGFR-2 Expression Levels

Biomolecules, 2019
Clinical trials have demonstrated the safety and efficacy of autologous endothelial progenitor cell (EPC) therapy in various diseases. Since EPCs’ functions are influenced by genetic, systemic and environmental factors, the therapeutic potential of
Nadin Sabbah, Tal Tamari, Rina Elimelech, Ofri Doppelt, Utai Rudich, Hadar Zigdon-Giladi   +5 more
doaj   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source