Results 171 to 180 of about 1,570,512 (298)

Beyond the Bone Marrow: A Case Report of Extramedullary Hematopoiesis in Advanced Primary Myelofibrosis. [PDF]

Cureus
Grisales Cano DA, Castellanos Olarte WA, Londoño Fonseca AM, Bonilla Cardona NJ, Salas Fernandez S.   +4 more
europepmc   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

The number of additional high molecular risk mutations predicts outcome after hematopoietic stem cell transplantation in primary and secondary myelofibrosis

Blood Cancer Journal
Maria Chiara Finazzi, Silvia Salmoiraghi, Francesca Valsecchi, Chiara Pavoni, Clara Belotti, Anna Grassi, Alessandra Algarotti, Federico Lussana, Benedetta Rambaldi, Giuliana Rizzuto, Gianluca Cavallaro, Annalisa Condorelli, Marta Bellini, Orietta Spinelli, Alessandro Rambaldi   +14 more
doaj   +1 more source

Dissecting bone marrow and plasma exosomal microRNA profiles following trauma. [PDF]

Surgery
Peethala A, Yoham AL, Bible LE, Kannan KB, Wheeler C, Hernández-Ríos M, Rodhouse CE, Maile R, Efron PA, Mohr AM.   +9 more
europepmc   +1 more source

Self‐Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic/Photothermal/Chemodynamic/Starvation Therapy for Eradication of Colon Cancer

Advanced Science, EarlyView.
The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang, Shibo Zhao, Wenying Wu, Zhiwei Duan, Yuan Li, Xiangyu Zeng, Liang Hong, Yan Chen, Ling Tao, Kewu Zeng, Chaoda Xiao, Xiangchun Shen   +11 more
wiley   +1 more source

Co-culture of bone marrow-derived macrophages with aged primary myoblasts. [PDF]

Biol Methods Protoc
Arsenault R, Ziadeh A, Green A, Dort J.
europepmc   +1 more source

NIR‐II Light‐Triggered Electron Flow Initiates Cuproptosis‐Centered Thermoelectric‐Immunotherapy for Breast Cancer

Advanced Science, EarlyView.
A NIR‐II light‐activatable thermoelectric nanoreactor converts surface‐bound Cu2+ into bioactive Cu+ via directed electron flow. This spatiotemporally controlled reduction triggers potent cuproptosis and immunogenic cell death, eradicating primary tumors and, together with aPD‐1 therapy, suppressing metastases while establishing durable immune memory ...
Boyu Yuan, Qin Fan, Shushu Chu, Shining Yang, Yuechao Yang, Chenxi Zhang, Jinqiao Zhang, Xinran Qu, Yiju Wei, Xin Wang, Ziliang Dong   +10 more
wiley   +1 more source

Expansion of bone marrow adipocytes in obese mice leads to PD-L1-driven bone marrow immunosuppression and osteoclastogenesis. [PDF]

Bone Res
Costa SN, Chlebek C, Gray L, Caradonna P, Ryzhov S, Rosen CJ.   +5 more
europepmc   +1 more source

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source

Clinical Associations of Osteoporosis in BCR::ABL1 Negative Myeloproliferative Neoplasms

International Journal of Endocrinology
Mürüvvet Seda Aydin, Simten Dagdas, Mehmet Sezgin Pepeler, Gülten Korkmaz, Aysel Alper, Elif Açıkgöz, Tugce Nur Bektas, Merve Pamukçuoğlu, Funda Ceran, Gulsum Ozet   +9 more
doaj   +1 more source