Results 181 to 190 of about 628,923 (267)

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Serum presepsin level reflects macrophage activation and hemophagocytosis in bone marrow. [PDF]

PLoS One
Yamanaka K, Furuhashi K, Shimoyama K, Okubo Y, Yukishima T, Sawada S, Adachi M, Yamashita K, Iwaizumi M, Nagata Y, Ono T, Ogawa N, Maekawa M, Baba S.   +13 more
europepmc   +1 more source

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy. [PDF]

Bone Res
Roy N, Liu H, Horenberg AL, Pathak AP, Chen J, Ramasamy SK, Cohen-Solal M, Bozec A, Grayson WL, Kusumbe AP.   +9 more
europepmc   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

The triple A (AAA) model globally recapitulates adverse outcomes in essential thrombocythemia

Blood Cancer Journal
Luca Tosoni, Gian Luca Morelli, Gaia Tomadini, Davide Lazzarotto, Carla Filì, Erica Simeone, Maria Elena Zannier, Chiara Callegari, Matteo Fanin, Giulia Battaglia, Melissa Bergnach, Daniela Damiani, Renato Fanin, Mario Tiribelli   +13 more
doaj   +1 more source

Resilience of the bone marrow vascular architecture to aging and hematological stress. [PDF]

Blood Vessel Thromb Hemost
Hemmen K, Manoj V, Göb V, Pinnecker J, Stegner D, Heinze KG.   +5 more
europepmc   +1 more source

Bone Marrow Transplantation

CA: A Cancer Journal for Clinicians, 1986
openaire   +2 more sources