Results 41 to 50 of about 2,328,469 (382)
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche
Nature Network Boston, 2018 Aging of hematopoietic stem cells (HSCs) is associated with a decline in their regenerative capacity and multilineage differentiation potential, contributing to the development of blood disorders.
Maria Maryanovich +11 more
semanticscholar +1 more source
Cell Transplantation, 2020 Stem cell transplantation remains the curative option for many patients with hematological malignancies. The long-term effects of these treatments on the patients and their immune systems have been extensively investigated, but there remains a paucity of
Rebecca Lloyd +13 more
doaj +1 more source
Multi-Contrast MRI Segmentation Trained on Synthetic Images [PDF]
arXiv, 2022 In our comprehensive experiments and evaluations, we show that it is possible to generate multiple contrast (even all synthetically) and use synthetically generated images to train an image segmentation engine. We showed promising segmentation results tested on real multi-contrast MRI scans when delineating muscle, fat, bone and bone marrow, all ...
arxiv
The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source
Molecular Cytogenetics, 2017 Background Myelodysplastic syndromes (MDS) are clonal stem cell disorders exhibiting cytopenias, ineffective hematopoiesis and morphological dysplasia. Bone marrow cytogenetics, inspite of being incorporated as mandatory tool in diagnosis are done less ...
Nida Anwar +7 more
doaj +1 more source
Journal of Clinical Pathology, 1972 Lipofuscins are commonly present in the macrophages of the marrow. In unstained preparations they may be confused with haemosiderin, but they are readily distinguished by fluorescence microscopy.In contrast to the belief that lipofuscins are a manifestation of senility, no age dependence has been demonstrated.Exceptionally large amounts have been found
K. G. A. Clark, W. M. Davidson
openaire +3 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Esophageal Plasmacytoma Revealed by Persistent Hiccups: A Case Report and Literature Review
Case Reports in Gastrointestinal Medicine, 2022 Introduction. Solitary extramedullary plasmacytoma (SEP) is a rare neoplasm that is derived from monoclonal proliferation of plasma cells in the soft tissues or organs arising outside the bone marrow.
Khaoula Khalil +2 more
doaj +1 more source
Towards a New Spatial Representation of Bone Remodeling [PDF]
, 2011 Irregular bone remodeling is associated with a number of bone diseases such as osteoporosis and multiple myeloma. Computational and mathematical modeling can aid in therapy and treatment as well as understanding fundamental biology. Different approaches to modeling give insight into different aspects of a phenomena so it is useful to have an arsenal ...
arxiv +1 more source
IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow
Journal of Experimental Medicine, 2018 Group 2 innate lymphoid cells (ILC2s) are effector cells within the mucosa and key participants in type 2 immune responses in the context of allergic inflammation and infection.
M. Stier +9 more
semanticscholar +1 more source