Results 71 to 80 of about 578,438 (161)

Ablation of Proliferating Marrow with 5‐Fluorouracil Allows Partial Purification of Mesenchymal Stem Cells [PDF]

, 2006
The ability to identify and maintain mesenchymal stem cells in vitro is a prerequisite for the ex vivo expansion of cells capable of effecting mesenchymal tissue regeneration. The aim of this investigation was to develop an assay to enrich and ultimately
Krebsbach, Paul H., Song, Junhui, Taichman, Russell S., Wang, Zhuo   +3 more
core   +1 more source

P887: IN-HOUSE ANTI BCMA CAR-T THERAPY FOR THE TREATMENT OF RELAPSED REFRACTORY MULTIPLE MYELOMA: PHASE 1 RESULTS.

HemaSphere, 2022
N. Asherie, S. Kfir-Erenfeld, B. Avni, S. Grisariu, M. Assayag, T. Sharon, E. Lebel, C. J. Cohen, M. E. Gatt, P. Stepensky   +9 more
doaj   +1 more source

Human placenta-derived endothelial progenitor cells: an animal-free culture system for efficient expansion

Biological Research
Background Endothelial progenitor cells (EPCs) play a critical role in vasculogenesis and vascular repair, but their clinical application is hindered by challenges such as cell purity, quantity, and reliance on fetal bovine serum (FBS).
Shengnan Yuan, Mengrou Li, Junhao Wang, Wen Ju, Yujin Huang, Yue Li, Haohan Fan, Lingyu Zeng   +7 more
doaj   +1 more source

Bone Marrow–on–a–Chip Replicates Hematopoietic Niche Physiology in Vitro [PDF]

, 2014
Current in vitro hematopoiesis models fail to demonstrate the cellular diversity and complex functions of living bone marrow; hence, most translational studies relevant to the hematologic system are conducted in live animals.
Collins, James J., Ingber, Donald Elliot, Mammoto, Akiko, Mammoto, Tadanori, Spina, Catherine, Tat, Tracy, Torisawa, Yu-suke, Weaver, James C.   +7 more
core   +1 more source

A focus on LBCL patients in partial remission in the CAR-T era

Frontiers in Hematology
The treatment paradigm for large B-cell lymphoma (LBCL) has undergone significant changes in recent years. Patients who fail to achieve a complete response (CR) after first-line therapy (1L) or relapse within 12 months are considered to have a poor ...
Giuseppe Tarantini, Elena Arcuti, Caterina Buquicchio, Vera Carluccio, Gaetano De Santis, Candida Rosaria Germano, Mariangela Leo, Daria Carmela Loconte, Sonia Mallano, Rosanna Maria Miccolis, Teresa Maria Santeramo, Vanda Strafella, Vincenzo Pavone   +12 more
doaj   +1 more source

Stem Cell Mobilization and Harvesting Failure in Case of Heavily Pretreated Patients

Journal of Interdisciplinary Medicine, 2017
Background: High-dose chemotherapy and autologous stem cell transplantation have become a standard curative treatment in various hematologic malignancies. Many factors can affect the success of mobilization and hematopoietic stem cell harvesting.
Mild Eszter, Lázár Erzsébet, Köpeczi Judit-Beáta, Kakucs Enikő, Găzdac Marius, Pakucs Annamária, Tudor Cezara, Benedek István   +7 more
doaj   +1 more source

Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors. [PDF]

, 2010
IntroductionThe interaction between the immune and skeletal systems is evidenced by the bone loss observed in autoimmune diseases such as rheumatoid arthritis. In this paper we describe a new mechanism by which the immune cytokine IL-17A directly affects
Adamopoulos, Iannis E, Blumenschein, Wendy, Bowman, Edward P, Chao, Cheng-Chi, Geissler, Richard, Iwakura, Yoichiro, Laface, Drake, McClanahan, Terrill   +7 more
core   +1 more source

P1340: RESPONSE RATES AND PROGNOSTIC FACTORS IN ACUTE GASTROINTESTINAL GRAFT-VERSUS-HOST DISEASE

HemaSphere, 2022
J. Freitas, M. Pimenta, E. Couto, P. Coelho, R. Branca, C. Pinho Vaz, L. Leite, A. Campos   +7 more
doaj   +1 more source

Avapritinib for targeting KIT D816V-mutated acute myeloid leukemia relapsed after allogeneic hematopoietic stem cell transplant with extramedullary and central nervous system involvement

Annals of Hematology
Relapse of acute myeloid leukemia with CBFB::MYH11 fusion and KIT D816V mutation after allogeneic hematopoietic stem cell transplantation is uncommon and often associated with aggressive extramedullary spread and poor outcomes, particularly when the ...
Marco Frigeni, Alessandra Algarotti, Silvia Salmoiraghi, Clara Belotti, Martina Milani, Chiara Pavoni, Orietta Spinelli, Irene Gotuzzo, Alessandro Rambaldi, Federico Lussana   +9 more
doaj   +1 more source

Unrelated Allogeneic Stem Cell Transplantation in a Patient with Chronic Myeloid Leukemia in Blast Crisis

Journal of Interdisciplinary Medicine, 2017
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder, which can involve the hematopoietic stem cell or early progenitor cells, without the loss of their capacity to differentiate.
Benedek István, Lázár Erzsébet, Köpeczi Judit Beáta, Benedek István, Tunyogi Aliz Beáta, Jakab Szende, Pakucs Annamária   +6 more
doaj   +1 more source