Results 81 to 90 of about 960,390 (294)

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

Comparative utility of bone marrow aspiration and trephine biopsy in evaluation of hematological disorders

Archives of Medicine and Health Sciences, 2020
Background: Bone marrow examination is a useful investigative tool to diagnose several hematological and nonhematological disorders. While the aspiration provides excellent cytological detail, the biopsy provides information regarding the spatial ...
Lekshmi Vijayamohanan, Sarita Asotra, Kavita Kumari, Pooja Murgai, Digvijay Dattal   +4 more
doaj   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Hemophagocytosis in bone marrow aspirates: An indication of hidden pathologies

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2019
Background and Objectives: Hemophagocytosis in bone marrow aspirates is fairly common and can be observed in a spectrum of clinical conditions. This study aimed at evaluating the clinicopathological profile of patients showing hemophagocytosis on bone ...
Sampath Kolavadi Srinivasagowda, Venkatesan Somasundaram, Vinu Balraam, Reena Bharadwaj   +3 more
doaj   +1 more source

Human endothelial-like differentiated precursor cells maintain their endothelial characteristics when cocultured with mesenchymal stem cell and seeded onto human cancellous bone [PDF]

, 2013
Introduction. Cancellous bone is frequently used for filling bone defects in a clinical setting. It provides favourable conditions for regenerative cells such as MSC and early EPC.
Marzi, Ingo, Dirk Henrich, Barker, John Howard, John Barker, Cancellous Bone, Henrich, Dirk, Ingo Marzi, Seebach, Caroline, Joerg Warzecha, Caroline Seebach, Wilhelm, Kerstin, Warzecha, Jörg, Frank, Johannes, Kerstin Wilhelm, Johannes Frank   +14 more
core   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Evaluation of bone marrow aspirate concentrate in non-union and delayed union of fractures

Journal of Dr. NTR University of Health Sciences
Introduction: Bone Marrow Aspirate Concentrate (BMAC) belongs to a class of materials known as Orthobiologics. When used in higher concentrations will enhance the bone healing.
Mrudhula Buddana, Harshavardhan Surath, Lakshmi Narayana Paladugu, Amarnath Surath   +3 more
doaj   +1 more source

Comparison between the effects of platelet-rich plasma and bone marrow concentrate on defect consolidation in the rabbit tibia

Clinics, 2011
OBJECTIVE: To perform a comparative analysis of the effects of platelet-rich plasma and centrifuged bone marrow aspirate on the induction of bone healing in rabbits.
Marco Antonio Batista, Tomaz Puga Leivas, Consuelo Junqueira Rodrigues, Géssica Cantadori Funes Arenas, Donizeti Rodrigues Belitardo, Roberto Guarniero   +5 more
doaj   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC)

, 2016
Degenerative and traumatic articular cartilage defects are common, difficult to treat, and progressive lesions that cause significant morbidity in the general population.
Ahmed, S., Kim, S., Shetty, A., Lee, D., Huh, S.   +4 more
core   +1 more source