Results 61 to 70 of about 6,967 (325)

Matrix-Associated Chondroplasty: A Novel Platelet-Rich Plasma and Concentrated Nucleated Bone Marrow Cell–Enhanced Cartilage Restoration Technique

Arthroscopy Techniques, 2014
Bone marrow stimulation techniques such as microfracture for the treatment of articular cartilage defects so far solely reproduce mechanically inferior fibrous cartilage tissue, which might result in unsatisfactory clinical results at midterm.
Matthias R. Steinwachs, M.D., Bernhard Waibl, M.D., Stephanie Wopperer, M.D., Marcus Mumme, M.D.   +3 more
doaj   +1 more source

Different methods of bone marrow harvesting influence cell characteristics and purity, affecting clinical outcomes

JVS - Vascular Science, 2023
Background: Bone marrow (BM)-derived stem cells were implanted to induce angiogenesis in patients with no-option critical limb-threatening ischemia. Considering the potential for this therapy, conflicting results related to BM harvesting methods have ...
Eugenio Caradonna, MD, Elisabetta Mormone, PhD, Enrico Maria Centritto, MD, Andrea Mazzanti, MD, PhD, Stefano Papini, MD, Mara Fanelli, PhD, Lella Petrella, PhD, Arnolfo Petruzziello, MD, Michele Angelo Farina, MD, Eleonora Farina, MD, Bruno Amato, MD, Carlo Maria De Filippo, MD, Emilio Vanoli, MD   +12 more
doaj   +1 more source

Acute Myeloid Leukemia [PDF]

, 2017
Acute myeloid leukemia (AML) is the most common type of leukemia. The Cancer Genome Atlas Research Network has demonstrated the increasing genomic complexity of acute myeloid leukemia (AML).
Fortina, P, Kricka, Lj, Londin, E, Park, Jy   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dry Arthroscopic Single-Stage Cartilage Repair of the Knee Using a Hyaluronic Acid-Based Scaffold With Activated Bone Marrow-Derived Mesenchymal Stem Cells

Arthroscopy Techniques, 2016
Cartilage lesions of the knee are a frequent finding; however, treatment options that are capable of restoring hyaline-like tissue are not routinely used. Cell-based technology such as autologous chondrocyte implantation may in some cases provide durable
Graeme P. Whyte, M.D., M.Sc., F.R.C.S.C., Alberto Gobbi, M.D., Boguslaw Sadlik, M.D., Ph.D.   +2 more
doaj   +1 more source

Transtendinous Rotator Cuff Tear Repair with Bone Marrow Aspirate Concentrate Dermal Allograft Augmentation

Arthroscopy Techniques, 2021
Rotator cuff tears involving the musculotendinous junction with a significant amount of tendon still attached to the footprint laterally represent a challenging scenario for shoulder arthroscopists.
Peter Neff, M.D., Don B. Franklin, III, M.D., Daniel L. Jones, M.D., Sarah D. Lang, M.Ed., A.T.C., O.T.C., Haley R. Nadone, M.S., Brian B. Gilmer, M.D., Dan Guttmann, M.D.   +6 more
doaj   +1 more source

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production [PDF]

, 2016
Background: Clinical translation of mesenchymal stromal cells (MSCs) necessitates basic characterization of the cell product since variability in biological source and processing of MSCs may impact therapeutic outcomes.
A. Noelle Larson, Allan B. Dietz, Amel Dudakovic, Andre J. van Wijnen, Catalina Galeano Garces, Christopher R. Paradise, Emily T. Camilleri, Hee-Jeong Im Sampen, Hideki Takai, Jay Smith, Marcel Karperien, Michael P. Gustafson, Scott M. Riester, Simon Cool, Wenchun Qu   +14 more
core   +3 more sources

Radiological outcome of hamstring graft after anterior cruciate ligament reconstruction with augmentation of bone marrow aspirate concentrate [PDF]

, 2021
Background: Anterior cruciate ligament (ACL) tears are common injuries in the athletic population. Surgical intervention is required for ACL tears as it restores the knee function and it prevents early osteoarthritis.
Bhamare, D. S., Desouza, Clevio, Nathani, Girish, Patil, Amol, Shevate, Ishan   +4 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Retroarticular Core Decompression with Biologic Augmentation for Juvenile Osteochondritis Dissecans of the Knee

Arthroscopy Techniques, 2020
Juvenile osteochondritis dissecans (OCD) of the knee is a rare condition of subchondral bone that has secondary effects on articular cartilage as the condition advances.
Steven M. Andelman, M.D., Bert R. Mandelbaum, M.D., Kevin P. Fitzsimmons, P.A.-C., J. Lee Pace, M.D.   +3 more
doaj   +1 more source