Results 61 to 70 of about 1,147,375 (265)

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Intra-Articular Bone Marrow Aspirate Concentrate Injection in Patients with Knee Osteoarthritis

Applied Sciences, 2020
We aimed to evaluate the 5-year follow-up outcomes of an intra-articular bone marrow aspirate concentrate (BMAC) injection in patients with knee osteoarthritis. This is the first study to report the outcomes following BMAC injections over a 5-year follow-
Gi Beom Kim, Jae-Do Kim, Young Choi, Chang Hyun Choi, Gun Woo Lee   +4 more
doaj   +1 more source

Does Needle Design Affect the Regenerative Potential of Bone Marrow Aspirate? An In Vitro Study

Life, 2021
While autologous bone is still the gold standard for treatment of bone defects, its availability is limited. Sufficient numbers of mesenchymal stroma cells (MSC) may be an alternative.
Nadia Feddahi, Monika Herten, Tjark Tassemeier, Heike Rekasi, Alexander Hackel, Marcel Haversath, Marcus Jäger   +6 more
doaj   +1 more source

Intra-articular injection of bone marrow aspirate concentrate (mesenchymal stem cells) in KL grade III and IV knee osteoarthritis: 4 year results of 37 knees

Scientific Reports
Cell based therapies are increasingly used and results of bone marrow aspirate concentrate (BMAC) show encouraging short- to middle term results, superior to hyaluronic acid and platelet rich plasma (PRP).
C. Pabinger, H. Lothaller, G. S. Kobinia
semanticscholar   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Augmenting an Allograft for Anterior Cruciate Ligament Reconstruction With a Collagen Matrix and Bone Marrow Aspirate Concentrate Injection Appears Safe and Produces Favorable Clinical Outcomes at 2-Year Follow-Up

Arthroscopy, Sports Medicine, and Rehabilitation
Purpose To evaluate clinical outcomes of augmenting an anterior cruciate ligament (ACL) allograft with an amnion matrix wrap and injecting bone marrow aspirate concentrate (BMAC).
Steve E. Jordan, A. Anz, Roger V. Ostrander, Eric A. Branch, Thomas S. Denney, Achraf Cohen, Jessica Truett, James R. Andrews   +7 more
semanticscholar   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Matrix-Associated Chondroplasty: A Novel Platelet-Rich Plasma and Concentrated Nucleated Bone Marrow Cell–Enhanced Cartilage Restoration Technique

Arthroscopy Techniques, 2014
Bone marrow stimulation techniques such as microfracture for the treatment of articular cartilage defects so far solely reproduce mechanically inferior fibrous cartilage tissue, which might result in unsatisfactory clinical results at midterm.
Matthias R. Steinwachs, M.D., Bernhard Waibl, M.D., Stephanie Wopperer, M.D., Marcus Mumme, M.D.   +3 more
doaj   +1 more source

Different methods of bone marrow harvesting influence cell characteristics and purity, affecting clinical outcomes

JVS - Vascular Science, 2023
Background: Bone marrow (BM)-derived stem cells were implanted to induce angiogenesis in patients with no-option critical limb-threatening ischemia. Considering the potential for this therapy, conflicting results related to BM harvesting methods have ...
Eugenio Caradonna, MD, Elisabetta Mormone, PhD, Enrico Maria Centritto, MD, Andrea Mazzanti, MD, PhD, Stefano Papini, MD, Mara Fanelli, PhD, Lella Petrella, PhD, Arnolfo Petruzziello, MD, Michele Angelo Farina, MD, Eleonora Farina, MD, Bruno Amato, MD, Carlo Maria De Filippo, MD, Emilio Vanoli, MD   +12 more
doaj   +1 more source

Bone marrow aspirate concentrate (BMAC) harvested in the axial and appendicular skeleton does not differ in progenitor cell count: A systematic review and meta-analysis.

Journal of Orthopaedics
Introduction Bone marrow aspirate concentrate (BMAC) is a reliable source of progenitor cells that facilitate healing, and it is typically harvested from the iliac crest.
Udit Dave, Jared Rubin, H. Shah, Cameron Gerhold, Johnathon R. McCormick, Andrew S. Bi, C. Yuh, L. Rossi, J. Chahla   +8 more
semanticscholar   +1 more source